Synthesis and Antifungal Activity of 2-Ketophenyl-3-substituted aryl-1-thiazolidin-4-ones
A new series of 2-ketophenyl-3-substituted aryl-1- thiazolidin-4-ones were synthesized by cyclocondensation of ketoazomethines and thioglycolic acid. Ketoazomethines were synthesized by condensation of phenyl glyoxal (prepared by partial oxidation of acetophenone) and various para-substituted anilin...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/979353 |
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| Summary: | A new series of 2-ketophenyl-3-substituted aryl-1- thiazolidin-4-ones were synthesized by cyclocondensation of ketoazomethines and thioglycolic acid. Ketoazomethines were synthesized by condensation of phenyl glyoxal (prepared by partial oxidation of acetophenone) and various para-substituted anilines. Their structures were elucidated by elemental analysis, IR and H1 NMR; they were screened for their antifungal activity against hazardous fungi namely Fusarium Oxysporum, Pythium, Sclerotium and Alternaria brassicola. |
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| ISSN: | 0973-4945 2090-9810 |