Real-world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral Ibuprofen and ketorolac in adult and pediatric patients
IntroductionIntravenous non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in healthcare settings, but their comparative safety and resource utilization impacts remain understudied. This study aimed to compare adverse drug reactions (ADRs) and healthcare resource utilization (HCRU) bet...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pain Research |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2024.1484948/full |
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| author | Mosadoluwa Afolabi Jensy Rodriguez-Silva Ishveen Chopra Ines Macias-Perez Jason Makii Emily Durr Theresa Human |
| author_facet | Mosadoluwa Afolabi Jensy Rodriguez-Silva Ishveen Chopra Ines Macias-Perez Jason Makii Emily Durr Theresa Human |
| author_sort | Mosadoluwa Afolabi |
| collection | DOAJ |
| description | IntroductionIntravenous non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in healthcare settings, but their comparative safety and resource utilization impacts remain understudied. This study aimed to compare adverse drug reactions (ADRs) and healthcare resource utilization (HCRU) between patients receiving IV-ibuprofen versus IV/IM ketorolac.MethodsA retrospective, longitudinal analysis was conducted using an all-payer database, examining records from January 1, 2014, to June 3, 2023. The study included both adult (≥18 years) and pediatric (<18 years) populations who received one or more doses of either medication. Propensity score matching was applied to both populations, and HCRU was tracked for 29 days post-final dose. The adult cohort included 31,046 IV-ibuprofen and 124,184 ketorolac records, while the pediatric cohort had 5,579 patients per treatment arm.ResultsBoth adult and pediatric patients receiving IV-ibuprofen demonstrated lower ADR incidence and reduced HCRU compared to those receiving ketorolac.DiscussionThe findings suggest IV-ibuprofen may be a safer alternative to ketorolac, potentially improving patient care outcomes while reducing healthcare system burden. These results have implications for clinical practice and healthcare resource management. |
| format | Article |
| id | doaj-art-1e9266aa5d004eba948193e48c04a4f9 |
| institution | Kabale University |
| issn | 2673-561X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj-art-1e9266aa5d004eba948193e48c04a4f92025-01-07T06:40:54ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2025-01-01510.3389/fpain.2024.14849481484948Real-world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral Ibuprofen and ketorolac in adult and pediatric patientsMosadoluwa Afolabi0Jensy Rodriguez-Silva1Ishveen Chopra2Ines Macias-Perez3Jason Makii4Emily Durr5Theresa Human6STATinMED, LLC, Dallas, TX, United StatesSTATinMED, LLC, Dallas, TX, United StatesSTATinMED, LLC, Dallas, TX, United StatesCumberland Pharmaceuticals, Nashville, TN, United StatesCumberland Pharmaceuticals, Nashville, TN, United StatesCumberland Pharmaceuticals, Nashville, TN, United StatesCumberland Pharmaceuticals, Nashville, TN, United StatesIntroductionIntravenous non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in healthcare settings, but their comparative safety and resource utilization impacts remain understudied. This study aimed to compare adverse drug reactions (ADRs) and healthcare resource utilization (HCRU) between patients receiving IV-ibuprofen versus IV/IM ketorolac.MethodsA retrospective, longitudinal analysis was conducted using an all-payer database, examining records from January 1, 2014, to June 3, 2023. The study included both adult (≥18 years) and pediatric (<18 years) populations who received one or more doses of either medication. Propensity score matching was applied to both populations, and HCRU was tracked for 29 days post-final dose. The adult cohort included 31,046 IV-ibuprofen and 124,184 ketorolac records, while the pediatric cohort had 5,579 patients per treatment arm.ResultsBoth adult and pediatric patients receiving IV-ibuprofen demonstrated lower ADR incidence and reduced HCRU compared to those receiving ketorolac.DiscussionThe findings suggest IV-ibuprofen may be a safer alternative to ketorolac, potentially improving patient care outcomes while reducing healthcare system burden. These results have implications for clinical practice and healthcare resource management.https://www.frontiersin.org/articles/10.3389/fpain.2024.1484948/fullNSAIDadverse drug reaction (ADR)intravenous ibuprofenketorolacside effecthealthcare resource utilization |
| spellingShingle | Mosadoluwa Afolabi Jensy Rodriguez-Silva Ishveen Chopra Ines Macias-Perez Jason Makii Emily Durr Theresa Human Real-world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral Ibuprofen and ketorolac in adult and pediatric patients Frontiers in Pain Research NSAID adverse drug reaction (ADR) intravenous ibuprofen ketorolac side effect healthcare resource utilization |
| title | Real-world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral Ibuprofen and ketorolac in adult and pediatric patients |
| title_full | Real-world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral Ibuprofen and ketorolac in adult and pediatric patients |
| title_fullStr | Real-world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral Ibuprofen and ketorolac in adult and pediatric patients |
| title_full_unstemmed | Real-world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral Ibuprofen and ketorolac in adult and pediatric patients |
| title_short | Real-world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral Ibuprofen and ketorolac in adult and pediatric patients |
| title_sort | real world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral ibuprofen and ketorolac in adult and pediatric patients |
| topic | NSAID adverse drug reaction (ADR) intravenous ibuprofen ketorolac side effect healthcare resource utilization |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2024.1484948/full |
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