An FMRI meta-analysis of interoception in eating disorders
Eating Disorders (EDs) are associated with disturbed interoception – the sense of the internal condition of the body. Disturbances in interoception across senses have not yet been comprehensively examined in EDs. To do so, we employed an innovative Bayesian author-topic model approach to fMRI meta-a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811924004300 |
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| author | Nandini Datta Anna Hughes Mattia Modafferi Megan Klabunde |
| author_facet | Nandini Datta Anna Hughes Mattia Modafferi Megan Klabunde |
| author_sort | Nandini Datta |
| collection | DOAJ |
| description | Eating Disorders (EDs) are associated with disturbed interoception – the sense of the internal condition of the body. Disturbances in interoception across senses have not yet been comprehensively examined in EDs. To do so, we employed an innovative Bayesian author-topic model approach to fMRI meta-analyses that pools together neural deficits across interoceptive senses and task types in participants with and recovered from EDs. Following PRISMA guidelines, our results combine activation patterns from 1,341 initially screened studies and data from 25 manuscripts that met study criteria that compare 463 patients with EDs (current or recovered) to 450 healthy control participants (HC). Altered brain activity was found within vision/sensory processing (precuneus), taste/self-referential processing (claustrum/posterior insula) and reward/set-shifting (global pallidus, medial frontal gyrus, anterior cingulate, precentral gyrus and parietal lobe) components in EDs compared to HC. Our results reveal separate components for bottom-up exteroceptive and interoceptive processing centering around the precuneus and claustrum/insula and also reward processing/set-shifting deficits. Thus, bottom-up sensory and reward processing are key deficits in EDs during ill and recovered states. |
| format | Article |
| id | doaj-art-1e8e744f4cfc4ff5a8410b846d2106ea |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-1e8e744f4cfc4ff5a8410b846d2106ea2025-01-11T06:38:29ZengElsevierNeuroImage1095-95722025-01-01305120933An FMRI meta-analysis of interoception in eating disordersNandini Datta0Anna Hughes1Mattia Modafferi2Megan Klabunde3Department of Psychiatry and Behavioural Science, Stanford University Medical Centre, Stanford CA, USADepartment of Psychology and Centre for Brain Sciences, University of Essex, Wivenhoe, CO4 3SQ United KingdomDepartment of Psychology and Centre for Brain Sciences, University of Essex, Wivenhoe, CO4 3SQ United KingdomDepartment of Psychology and Centre for Brain Sciences, University of Essex, Wivenhoe, CO4 3SQ United Kingdom; Corresponding author at: University of Essex, Wivenhoe Park, CO4 3SQ, United Kingdom.Eating Disorders (EDs) are associated with disturbed interoception – the sense of the internal condition of the body. Disturbances in interoception across senses have not yet been comprehensively examined in EDs. To do so, we employed an innovative Bayesian author-topic model approach to fMRI meta-analyses that pools together neural deficits across interoceptive senses and task types in participants with and recovered from EDs. Following PRISMA guidelines, our results combine activation patterns from 1,341 initially screened studies and data from 25 manuscripts that met study criteria that compare 463 patients with EDs (current or recovered) to 450 healthy control participants (HC). Altered brain activity was found within vision/sensory processing (precuneus), taste/self-referential processing (claustrum/posterior insula) and reward/set-shifting (global pallidus, medial frontal gyrus, anterior cingulate, precentral gyrus and parietal lobe) components in EDs compared to HC. Our results reveal separate components for bottom-up exteroceptive and interoceptive processing centering around the precuneus and claustrum/insula and also reward processing/set-shifting deficits. Thus, bottom-up sensory and reward processing are key deficits in EDs during ill and recovered states.http://www.sciencedirect.com/science/article/pii/S1053811924004300AnorexiaBulimiaEating disordersfMRIMeta-analyses and interoception |
| spellingShingle | Nandini Datta Anna Hughes Mattia Modafferi Megan Klabunde An FMRI meta-analysis of interoception in eating disorders NeuroImage Anorexia Bulimia Eating disorders fMRI Meta-analyses and interoception |
| title | An FMRI meta-analysis of interoception in eating disorders |
| title_full | An FMRI meta-analysis of interoception in eating disorders |
| title_fullStr | An FMRI meta-analysis of interoception in eating disorders |
| title_full_unstemmed | An FMRI meta-analysis of interoception in eating disorders |
| title_short | An FMRI meta-analysis of interoception in eating disorders |
| title_sort | fmri meta analysis of interoception in eating disorders |
| topic | Anorexia Bulimia Eating disorders fMRI Meta-analyses and interoception |
| url | http://www.sciencedirect.com/science/article/pii/S1053811924004300 |
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