Development of the Composition and Technology for Production a Solid Dispersion System by Hot Melt Extrusion to Increase the Bioavailability of the Active Substance

Development of the Composition and Technology for Production a Solid Dispersion System by Hot Melt Extrusion to Increase the Bioavailability of the Active Substance

Introduction. The solubility of an active pharmaceutical ingredient plays a major role in drug absorption. Hot melt extrusion is a batch or continuous process that allows creating solid dispersion systems based on various carriers in order to increase solubility and bioavailability of active substan...

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Bibliographic Details
Main Authors: K. A. Gusev, D. N. Maimistov, V. I. Pavlovsky, A. R. Aliev, A. V. Pavlovsky, O. V. Ivanova, D. O. Tsyrenov, E. V. Flisyuk
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2022-11-01
Series:Разработка и регистрация лекарственных средств
Subjects:
analgesic
1,4-benzodiazepine
hot melt extrusion
extrudate
solid dispersion
solubility
bioavailability
Online Access:https://www.pharmjournal.ru/jour/article/view/1367
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