Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions
Non-invasive brain stimulation (NIBS) techniques are designed to precisely and selectively target specific brain regions, thus enabling focused modulation of neural activity. Among NIBS technologies, low-intensity transcranial focused ultrasound (tFUS) has emerged as a promising new modality. The ap...
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MDPI AG
2024-10-01
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| Online Access: | https://www.mdpi.com/2076-3425/14/11/1095 |
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| author | Ahmadreza Keihani Claudio Sanguineti Omeed Chaichian Chloe A. Huston Caitlin Moore Cynthia Cheng Sabine A. Janssen Francesco L. Donati Ahmad Mayeli Khaled Moussawi Mary L. Phillips Fabio Ferrarelli |
| author_facet | Ahmadreza Keihani Claudio Sanguineti Omeed Chaichian Chloe A. Huston Caitlin Moore Cynthia Cheng Sabine A. Janssen Francesco L. Donati Ahmad Mayeli Khaled Moussawi Mary L. Phillips Fabio Ferrarelli |
| author_sort | Ahmadreza Keihani |
| collection | DOAJ |
| description | Non-invasive brain stimulation (NIBS) techniques are designed to precisely and selectively target specific brain regions, thus enabling focused modulation of neural activity. Among NIBS technologies, low-intensity transcranial focused ultrasound (tFUS) has emerged as a promising new modality. The application of tFUS can safely and non-invasively stimulate deep brain structures with millimetric precision, offering distinct advantages in terms of accessibility to non-cortical regions over other NIBS methods. However, to date, several tFUS aspects still need to be characterized; furthermore, there are only a handful of studies that have utilized tFUS in psychiatric populations. This narrative review provides an up-to-date overview of key aspects of this NIBS technique, including the main components of a tFUS system, the neuronavigational tools used to precisely target deep brain regions, the simulations utilized to optimize the stimulation parameters and delivery of tFUS, and the experimental protocols employed to evaluate the efficacy of tFUS in psychiatric disorders. The main findings from studies in psychiatric populations are presented and discussed, and future directions are highlighted. |
| format | Article |
| id | doaj-art-1e22cdca7afb4ba296c2bba97c5ee624 |
| institution | Kabale University |
| issn | 2076-3425 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-1e22cdca7afb4ba296c2bba97c5ee6242024-11-26T17:54:57ZengMDPI AGBrain Sciences2076-34252024-10-011411109510.3390/brainsci14111095Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future DirectionsAhmadreza Keihani0Claudio Sanguineti1Omeed Chaichian2Chloe A. Huston3Caitlin Moore4Cynthia Cheng5Sabine A. Janssen6Francesco L. Donati7Ahmad Mayeli8Khaled Moussawi9Mary L. Phillips10Fabio Ferrarelli11Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Neurology, University of California, San Francisco, CA 94143, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USANon-invasive brain stimulation (NIBS) techniques are designed to precisely and selectively target specific brain regions, thus enabling focused modulation of neural activity. Among NIBS technologies, low-intensity transcranial focused ultrasound (tFUS) has emerged as a promising new modality. The application of tFUS can safely and non-invasively stimulate deep brain structures with millimetric precision, offering distinct advantages in terms of accessibility to non-cortical regions over other NIBS methods. However, to date, several tFUS aspects still need to be characterized; furthermore, there are only a handful of studies that have utilized tFUS in psychiatric populations. This narrative review provides an up-to-date overview of key aspects of this NIBS technique, including the main components of a tFUS system, the neuronavigational tools used to precisely target deep brain regions, the simulations utilized to optimize the stimulation parameters and delivery of tFUS, and the experimental protocols employed to evaluate the efficacy of tFUS in psychiatric disorders. The main findings from studies in psychiatric populations are presented and discussed, and future directions are highlighted.https://www.mdpi.com/2076-3425/14/11/1095non-invasive brain stimulationtranscranial focused ultrasoundpsychiatric disorders |
| spellingShingle | Ahmadreza Keihani Claudio Sanguineti Omeed Chaichian Chloe A. Huston Caitlin Moore Cynthia Cheng Sabine A. Janssen Francesco L. Donati Ahmad Mayeli Khaled Moussawi Mary L. Phillips Fabio Ferrarelli Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions Brain Sciences non-invasive brain stimulation transcranial focused ultrasound psychiatric disorders |
| title | Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions |
| title_full | Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions |
| title_fullStr | Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions |
| title_full_unstemmed | Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions |
| title_short | Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions |
| title_sort | transcranial focused ultrasound neuromodulation in psychiatry main characteristics current evidence and future directions |
| topic | non-invasive brain stimulation transcranial focused ultrasound psychiatric disorders |
| url | https://www.mdpi.com/2076-3425/14/11/1095 |
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