Hydrophobic starch acetate nanoparticles: A biopolymer-based system for sustained antitubercular drug release
The objective of the research was to evaluate the utilization of starch acetate nanoparticles (SANPs) as drug delivery carriers for antitubercular drugs (Isoniazid, Rifampicin, and Pyrazinamide). The SANPs were synthesized employing ultrasonic-assisted double emulsification solvent evaporation metho...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Next Nanotechnology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949829524000810 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846138076038955008 |
|---|---|
| author | Gaurang Rami Pruthviraj Limbachiya Mohyuddin Maradiya Girish Acharya Jabali Vora |
| author_facet | Gaurang Rami Pruthviraj Limbachiya Mohyuddin Maradiya Girish Acharya Jabali Vora |
| author_sort | Gaurang Rami |
| collection | DOAJ |
| description | The objective of the research was to evaluate the utilization of starch acetate nanoparticles (SANPs) as drug delivery carriers for antitubercular drugs (Isoniazid, Rifampicin, and Pyrazinamide). The SANPs were synthesized employing ultrasonic-assisted double emulsification solvent evaporation method, permitting effective drug encapsulation. Chemical modification of native starch strengthened its hydrophobicity, as indicated by lower crystallinity in XRD analysis. The TGA validated the thermal stability of SANPs. Morphological investigation indicated a beehive-like structure with constant porosity changed to evenly dispersed spherical nanoparticles when Starch acetate is converted into SANPs. Dynamic light scattering measured the particle sizes of SANPs to be 161 nm. Drug encapsulation brought up the SANPs particle size to 249 nm. Isoniazid, Rifampicin, and Pyrazinamide exhibited 72 %, 83 %, and 75 % encapsulation efficiency at a 2:1 polymer-drug ratio, respectively. In phosphate-buffered saline (pH 7.4), drug release behavior exhibited 55 %, 30 %, and 45 % release of isoniazid, rifampicin, and pyrazinamide over 24 hours. The Korsmeyer-Peppas model demonstrated non-Fickian diffusion for all drug-encapsulated SANPs. Thus, these results contribute to the development of biopolymer-based drug delivery systems for sustainable release of antitubercular drugs. |
| format | Article |
| id | doaj-art-1e174dd426ce49b99c99282d77355b92 |
| institution | Kabale University |
| issn | 2949-8295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Nanotechnology |
| spelling | doaj-art-1e174dd426ce49b99c99282d77355b922024-12-07T08:35:22ZengElsevierNext Nanotechnology2949-82952025-01-017100120Hydrophobic starch acetate nanoparticles: A biopolymer-based system for sustained antitubercular drug releaseGaurang Rami0Pruthviraj Limbachiya1Mohyuddin Maradiya2Girish Acharya3Jabali Vora4Shree Sarvajanik Science College (PG), Mehsana, Gujarat 384001, India; Department of Chemistry, Hemchandracharya North Gujarat University, Patan, Gujarat 384265, IndiaDepartment of chemistry, R. R. Mehta College of Science & C. L. Parikh college of commerce, Palanpur, Gujarat 385001, India; Corresponding author.Department of Chemistry, Hemchandracharya North Gujarat University, Patan, Gujarat 384265, IndiaDepartment of chemistry, R. R. Mehta College of Science & C. L. Parikh college of commerce, Palanpur, Gujarat 385001, IndiaDepartment of Chemistry, Hemchandracharya North Gujarat University, Patan, Gujarat 384265, IndiaThe objective of the research was to evaluate the utilization of starch acetate nanoparticles (SANPs) as drug delivery carriers for antitubercular drugs (Isoniazid, Rifampicin, and Pyrazinamide). The SANPs were synthesized employing ultrasonic-assisted double emulsification solvent evaporation method, permitting effective drug encapsulation. Chemical modification of native starch strengthened its hydrophobicity, as indicated by lower crystallinity in XRD analysis. The TGA validated the thermal stability of SANPs. Morphological investigation indicated a beehive-like structure with constant porosity changed to evenly dispersed spherical nanoparticles when Starch acetate is converted into SANPs. Dynamic light scattering measured the particle sizes of SANPs to be 161 nm. Drug encapsulation brought up the SANPs particle size to 249 nm. Isoniazid, Rifampicin, and Pyrazinamide exhibited 72 %, 83 %, and 75 % encapsulation efficiency at a 2:1 polymer-drug ratio, respectively. In phosphate-buffered saline (pH 7.4), drug release behavior exhibited 55 %, 30 %, and 45 % release of isoniazid, rifampicin, and pyrazinamide over 24 hours. The Korsmeyer-Peppas model demonstrated non-Fickian diffusion for all drug-encapsulated SANPs. Thus, these results contribute to the development of biopolymer-based drug delivery systems for sustainable release of antitubercular drugs.http://www.sciencedirect.com/science/article/pii/S2949829524000810Hydrophobic starchAntitubercular drugsDrug delivery carriersKorsmeyer-Peppas modelUltrasonication |
| spellingShingle | Gaurang Rami Pruthviraj Limbachiya Mohyuddin Maradiya Girish Acharya Jabali Vora Hydrophobic starch acetate nanoparticles: A biopolymer-based system for sustained antitubercular drug release Next Nanotechnology Hydrophobic starch Antitubercular drugs Drug delivery carriers Korsmeyer-Peppas model Ultrasonication |
| title | Hydrophobic starch acetate nanoparticles: A biopolymer-based system for sustained antitubercular drug release |
| title_full | Hydrophobic starch acetate nanoparticles: A biopolymer-based system for sustained antitubercular drug release |
| title_fullStr | Hydrophobic starch acetate nanoparticles: A biopolymer-based system for sustained antitubercular drug release |
| title_full_unstemmed | Hydrophobic starch acetate nanoparticles: A biopolymer-based system for sustained antitubercular drug release |
| title_short | Hydrophobic starch acetate nanoparticles: A biopolymer-based system for sustained antitubercular drug release |
| title_sort | hydrophobic starch acetate nanoparticles a biopolymer based system for sustained antitubercular drug release |
| topic | Hydrophobic starch Antitubercular drugs Drug delivery carriers Korsmeyer-Peppas model Ultrasonication |
| url | http://www.sciencedirect.com/science/article/pii/S2949829524000810 |
| work_keys_str_mv | AT gaurangrami hydrophobicstarchacetatenanoparticlesabiopolymerbasedsystemforsustainedantituberculardrugrelease AT pruthvirajlimbachiya hydrophobicstarchacetatenanoparticlesabiopolymerbasedsystemforsustainedantituberculardrugrelease AT mohyuddinmaradiya hydrophobicstarchacetatenanoparticlesabiopolymerbasedsystemforsustainedantituberculardrugrelease AT girishacharya hydrophobicstarchacetatenanoparticlesabiopolymerbasedsystemforsustainedantituberculardrugrelease AT jabalivora hydrophobicstarchacetatenanoparticlesabiopolymerbasedsystemforsustainedantituberculardrugrelease |