Deferoxamine-related bilateral maculopathy with optical coherence tomography findings
Background: We present a case of bilateral maculopathy associated with deferoxamine mesylate (DFO) treatment. Methods: A 53-year-old man with myelodysplastic syndrome (MDS) received DFO therapy due to elevated ferritin levels. He was then referred to ophthalmology clinic due to blurred vision. He wa...
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| Format: | Article |
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100023006907 |
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| author | Neslihan Bayraktar Bilen Burcu Polat Gültekin Simten Dagdas Defne Kalayci |
| author_facet | Neslihan Bayraktar Bilen Burcu Polat Gültekin Simten Dagdas Defne Kalayci |
| author_sort | Neslihan Bayraktar Bilen |
| collection | DOAJ |
| description | Background: We present a case of bilateral maculopathy associated with deferoxamine mesylate (DFO) treatment. Methods: A 53-year-old man with myelodysplastic syndrome (MDS) received DFO therapy due to elevated ferritin levels. He was then referred to ophthalmology clinic due to blurred vision. He was diagnosed as bilateral neurosensory retinal detachment of the macula. During follow up, best corrected visual acuity (BCVA), optical coherence tomography (OCT), fundus fluorescein angiography (FFA), and fundus autofluorescence (FAF) were evaluated. Results: At first visit, OCT showed bilateral foveal neurosensory detachment. Hyperfluorescence of the macula and the peripapillary region were found on FFA. After discontinuation of DFO, BCVA improved from 20/120 to 20/60 with resolution of the foveal detachments on OCT scan. Four weeks later, FAF showed bilateral mottled hyperautofluorescence and hypoautofluorescence at the macula and the peripapillary region. Conclusion: Deferoxamine can cause acute retinal toxicity. Haematologists should be alert to visual complaints associated with DFO therapy, as early diagnosis and discontinuation of the medication allows recovery of visual function with residual fundus findings. |
| format | Article |
| id | doaj-art-1e0de8ddb0e74308843fc744b9a7569d |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-1e0de8ddb0e74308843fc744b9a7569d2024-12-11T05:55:31ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-0145103961Deferoxamine-related bilateral maculopathy with optical coherence tomography findingsNeslihan Bayraktar Bilen0Burcu Polat Gültekin1Simten Dagdas2Defne Kalayci3Department of Ophthalmology, Ankara Bilkent City Hospital, Üniversiteler Mahallesi 1604. Cadde No: 9, Gayret Mah. Oruc Reis Sk. Parkciftlik Konutlari CK-6/17, Yenimahalle, Çankaya, Ankara, Turkey; Corresponding author.Department of Ophthalmology, Veni Vidi Hospital, Ataşehir, Mavişehir Kipa Kavşağı, 8258/3. Sokak No: 4, Çiğli, İzmir 35640, TurkeyDepartment of Hematology, Ankara Bilkent City Hospital, Üniversiteler Mahallesi 1604. Cadde No: 9 Çankaya, Ankara, TurkeyDepartment of Ophthalmology, Ankara Bilkent City Hospital, Üniversiteler Mahallesi 1604. Cadde No: 9, Gayret Mah. Oruc Reis Sk. Parkciftlik Konutlari CK-6/17, Yenimahalle, Çankaya, Ankara, TurkeyBackground: We present a case of bilateral maculopathy associated with deferoxamine mesylate (DFO) treatment. Methods: A 53-year-old man with myelodysplastic syndrome (MDS) received DFO therapy due to elevated ferritin levels. He was then referred to ophthalmology clinic due to blurred vision. He was diagnosed as bilateral neurosensory retinal detachment of the macula. During follow up, best corrected visual acuity (BCVA), optical coherence tomography (OCT), fundus fluorescein angiography (FFA), and fundus autofluorescence (FAF) were evaluated. Results: At first visit, OCT showed bilateral foveal neurosensory detachment. Hyperfluorescence of the macula and the peripapillary region were found on FFA. After discontinuation of DFO, BCVA improved from 20/120 to 20/60 with resolution of the foveal detachments on OCT scan. Four weeks later, FAF showed bilateral mottled hyperautofluorescence and hypoautofluorescence at the macula and the peripapillary region. Conclusion: Deferoxamine can cause acute retinal toxicity. Haematologists should be alert to visual complaints associated with DFO therapy, as early diagnosis and discontinuation of the medication allows recovery of visual function with residual fundus findings.http://www.sciencedirect.com/science/article/pii/S1572100023006907Deferoxamine toxicityMaculopathyOptical coherence tomographyRetina |
| spellingShingle | Neslihan Bayraktar Bilen Burcu Polat Gültekin Simten Dagdas Defne Kalayci Deferoxamine-related bilateral maculopathy with optical coherence tomography findings Photodiagnosis and Photodynamic Therapy Deferoxamine toxicity Maculopathy Optical coherence tomography Retina |
| title | Deferoxamine-related bilateral maculopathy with optical coherence tomography findings |
| title_full | Deferoxamine-related bilateral maculopathy with optical coherence tomography findings |
| title_fullStr | Deferoxamine-related bilateral maculopathy with optical coherence tomography findings |
| title_full_unstemmed | Deferoxamine-related bilateral maculopathy with optical coherence tomography findings |
| title_short | Deferoxamine-related bilateral maculopathy with optical coherence tomography findings |
| title_sort | deferoxamine related bilateral maculopathy with optical coherence tomography findings |
| topic | Deferoxamine toxicity Maculopathy Optical coherence tomography Retina |
| url | http://www.sciencedirect.com/science/article/pii/S1572100023006907 |
| work_keys_str_mv | AT neslihanbayraktarbilen deferoxaminerelatedbilateralmaculopathywithopticalcoherencetomographyfindings AT burcupolatgultekin deferoxaminerelatedbilateralmaculopathywithopticalcoherencetomographyfindings AT simtendagdas deferoxaminerelatedbilateralmaculopathywithopticalcoherencetomographyfindings AT defnekalayci deferoxaminerelatedbilateralmaculopathywithopticalcoherencetomographyfindings |