Screening kinase inhibitors identifies MELK as a prime target against influenza virus infections through inhibition of viral mRNA splicing

Screening kinase inhibitors identifies MELK as a prime target against influenza virus infections through inhibition of viral mRNA splicing

Influenza epidemics represent a significant threat to global public health, primarily caused by the influenza viruses A and B. Although antiviral drugs targeting the influenza virus, such as zanamivir and oseltamivir, are clinically available, the emergence of virus evolution and drug resistance nec...

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Bibliographic Details
Main Authors: Xuanye Yang, Xili Feng, Qianyun Liu, Lele An, Zhongren Ma, Xiaoxia Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Microbiology
Subjects:
influenza virus
MELK
kinase inhibitor
antiviral agent
combination therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1600935/full
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