Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research

Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research

Abstract Cheek swabs, heterogeneous samples consisting primarily of buccal epithelial cells, are widely used in pediatric DNA methylation studies and biomarker creation. However, the decrease in buccal proportion with age in adults remains unexamined in childhood. We analyzed cheek swabs from 4626 t...

Full description

Saved in:

Bibliographic Details
Main Authors:	Sarah M. Merrill, Chaini Konwar, Fizza Fatima, Kristy Dever, Julia L. MacIsaac, Nicole Letourneau, Gerald F. Giesbrecht, Deborah Dewey, Gillian England-Mason, Candace R. Lewis, Dennis Wang, Ai Ling Teh, Michael J. Meaney, Andrea Gonzalez, Jennie G. Noll, Carolina De Weerth, Nicole R. Bush, Kieran J. O’Donnell, S. Evelyn Stewart, Michael S. Kobor
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-025-55909-8
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Buccal health in asthmatic patients.
by: Nora Sexto Delgado, et al.
Published: (2003-04-01)

Oral Neurothekeoma of the Right Buccal Mucosa
by: Alex C. Tham, et al.
Published: (2016-01-01)

Dental prosthesis and buccal lesions in the elderly
by: Beatriz García Alpizar, et al.
Published: (2010-02-01)

Giant Lipoma Presents from the Buccal Vestibule
by: Yuki Sakamoto, et al.
Published: (2020-01-01)

Clinical, Imaging and Histopathology of Angioleiomyoma of the Buccal Cheek
by: Mohammad Jafarian, et al.
Published: (2021-01-01)

Solitary Fibrous Tumor Arising in the Buccal Space
by: Tatsuo Okui, et al.
Published: (2019-01-01)

Buccal ureteroplasty options, techniques, long-term results
by: A. A. Volkov, et al.
Published: (2022-06-01)

Educational and therapeutic intervention in children with deforming buccal habits.
by: Jeny Fernández Martínez, et al.
Published: (2009-04-01)

Influence of buccal mucosa width/height ratio, emergence profile and buccal bone width on peri-implant tissues: a prospective one-year study
by: Yiman Tang, et al.
Published: (2025-01-01)

Metastatic Uterine Leiomyosarcoma in the Upper Buccal Gingiva Misdiagnosed as an Epulis
by: Andrea Cassoni, et al.
Published: (2014-01-01)

Educational program on buccal health for mothers of preschool age children.
by: Tania Menguez Becerra, et al.
Published: (2009-04-01)

Educative intervention for knowledge development on buccal health in elementary school.
by: Olga Lidia García Álvarez, et al.
Published: (2008-08-01)

Three-Layered Closure of Persistent Oroantral Fistula Using Chin Graft, Buccal Fat Pad, and Buccal Advancement Flap: A Case Report with Review of Literature
by: Shiv Prasad Sharma
Published: (2019-01-01)

The buccal plug: A technique for management of focal cicatricial entropion and trichiasis
by: Persiana S Saffari, et al.
Published: (2025-02-01)

A Foreign Body Granuloma of the Buccal Mucosa Induced by Honeybee Sting
by: Kazuhiko Yamamoto, et al.
Published: (2017-01-01)

Extramedullary Plasmacytoma of the Oral Cavity: A Rare Case in the Buccal Mucosa
by: Armin Khaleghi, et al.
Published: (2025-01-01)

Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae.
by: Hilary T Brewis, et al.
Published: (2025-01-01)

Advanced flow cell design for in vitro release testing of mucoadhesive buccal films
by: Grilc Blaž, et al.
Published: (2020-09-01)

Buccal habits: frequency and clinic appearance in children between 5 and 11 years
by: Maureen Janette Más García, et al.
Published: (2009-04-01)

Intravascular Papillary Endothelial Hyperplasia of Buccal Mucosa Masquerading as Mucocele - A Case Report
by: Deepak Pandiar, et al.
Published: (2023-10-01)

A Case of Buccal Abscess from an Impacted Wisdom Tooth in an Elderly Person with Malnutrition
by: Yuki Kojima, et al.
Published: (2016-01-01)

Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain
by: Hussain Amjad, et al.
Published: (2016-06-01)

Spindle Cell Lipoma Occurring in the Buccal Mucosa: An Unusual Location of This Benign Lipomatous Neoplasm
by: Noala Vicensoto Moreira Milhan, et al.
Published: (2015-01-01)

Interdisciplinary Management of Maxillary Canine Buccal Ectopia Associated with Peg Shaped Lateral Incisor
by: Karuna Singh Sawhny, et al.
Published: (2016-01-01)

Deforming buccal habits in children between 5 and 11 years old in Cienfuegos. 2005.
by: Odalys Acevedo Sierra, et al.
Published: (2008-08-01)

Supporting Mothers’ Engagement in a Community-Based Methadone Treatment Program
by: Nicole Letourneau, et al.
Published: (2013-01-01)

Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature
by: Durga Paudel, et al.
Published: (2019-01-01)

Manufacture and Characterization of Mucoadhesive Buccal Films Based on Pectin and Gellan Gum Containing Triamcinolone Acetonide
by: Felipe Pereira Fernandes, et al.
Published: (2018-01-01)

Verrucous Carcinoma of Buccal Mucosa in Female: A Rare Case Report of Traumatic Tooth Origin
by: V. Keerthi Narayan
Published: (2021-01-01)

Cytomorphometric analysis of buccal mucosal cells in iron deficiency anemia: A cross-sectional study
by: S Patil Swati, et al.
Published: (2023-07-01)

“A rare unfolding of buccal fibrolipoma—A remarkable oversized benign tumor in the oral cavity”
by: Rizwan Ahmad, et al.
Published: (2024-03-01)

Carcinoma Buccal Mucosa Underlying a Giant Cutaneous Horn: A Case Report and Review of the Literature
by: Sunil Kumar, et al.
Published: (2014-01-01)

Epidemiological study on Buccal Health in the 12 years old population of Health Care Area VIII in Cienfuegos.
by: Yumaidi Colina Sánchez, et al.
Published: (2007-08-01)

Immunohistochemical Localization of Epidermal Growth Factor Receptor in Rat Buccal Mucosa Treated with Fenugreek Leaf Oil
by: Sarah A Omran, et al.
Published: (2024-12-01)

Immunotherapy revolutionizing buccal carcinoma treatment: Harnessing immune checkpoint inhibitors to overcome immune evasion mechanisms
by: S. Menaka
Published: (2024-06-01)

Efficacy of Articaine versus Lignocaine as Local Anesthetic Agents Using Buccal Infiltration Technique for Extraction of Mandibular Premolars
by: Deepak Kolte, et al.
Published: (2024-12-01)

Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes
by: Pankaj V. Dangre, et al.
Published: (2019-01-01)

Re-defining pT4b buccal mucosa squamous cell carcinoma: Looking beyond palliation in select patients
by: Prateek V. Jain, et al.
Published: (2024-09-01)

Beyond detection rate: understanding the vigilance decrement using signal detection theory
by: Henri Etel Skinner, et al.
Published: (2025-01-01)

Endodontic Management of a Maxillary First Molar with Two Palatal Canals and a Single Buccal Canal: A Case Report
by: Leila Atash biz Yeganeh, et al.
Published: (2012-01-01)