Mining functional gene modules by multi-view NMF of phenome-genome association

Mining functional gene modules by multi-view NMF of phenome-genome association

Abstract Background Mining functional gene modules from genomic data is an important step to detect gene members of pathways or other relations such as protein-protein interactions. This work explores the plausibility of detecting functional gene modules by factorizing gene-phenotype association mat...

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Bibliographic Details
Main Authors: Xu Jin, WenQian He, MingMing Liu, Lin Wang, YaoGong Zhang, YingJie Xu, Ling Ma, YaLou Huang, MaoQiang Xie
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Genomics
Subjects:
Nonnegative matrix factorization
Gene module mining
Phenotype ontology
Hierarchical structure
Online Access:https://doi.org/10.1186/s12864-024-11120-5
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