OH2 oncolytic virus inhibits non-small-cell lung cancer metastasis via β-catenin pathway suppression

OH2 oncolytic virus inhibits non-small-cell lung cancer metastasis via β-catenin pathway suppression

Abstract The five-year survival rate for non-small-cell lung cancer (NSCLC) remains poor, primarily due to tumor invasion and metastasis. This study evaluates the anti-metastatic potential of the oncolytic virus OH2 in NSCLC. OH2 inhibits migration and invasion of NSCLC by downregulating β-catenin,...

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Main Authors: Han Hu, Qi Shen, Lingfang Zhang, Shuaiqi Zhu, Yining Cheng, Haixiao Duan, Fan Zhang, Lin Wang, Yuling Jin, Jinjin Cao, Yang Wang, Binlei Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08520-y
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