Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome
The hair follicle is a complex of mesenchymal and epithelial cells acquiring different properties and characteristics responsible for fulfilling its inductive and regenerative role. The epidermal and dermal crosstalk induces morphogenesis and maintains hair follicle cycling properties. The hair foll...
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2024-12-01
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| author | Ons Ben Hamida Moon Kyu Kim Young Kwan Sung Min Kyu Kim Mi Hee Kwack |
| author_facet | Ons Ben Hamida Moon Kyu Kim Young Kwan Sung Min Kyu Kim Mi Hee Kwack |
| author_sort | Ons Ben Hamida |
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| description | The hair follicle is a complex of mesenchymal and epithelial cells acquiring different properties and characteristics responsible for fulfilling its inductive and regenerative role. The epidermal and dermal crosstalk induces morphogenesis and maintains hair follicle cycling properties. The hair follicle is enriched with pluripotent stem cells, where dermal papilla (DP) cells and dermal sheath (DS) cells constitute the dermal compartment and the epithelial stem cells existing in the bulge region exert their regenerative role by mediating the epithelial–mesenchymal interaction (EMI). Many studies have developed and focused on various methods to optimize the EMI through in vivo and in vitro approaches for hair regeneration. The culturing of human hair mesenchymal cells resulted in the loss of trichogenicity and inductive properties of DP cells, limiting their potential application in de novo hair follicle generation in vivo. Epithelial stem cells derived from human hair follicles are challenging to isolate and culture, making it difficult to obtain enough cells for hair regeneration purposes. Mesenchymal stem cells and epithelial stem cells derived from human hair follicles lose their ability to form hair follicles during culture, limiting the study of hair follicle formation in vivo. Therefore, many attempts and methods have been developed to overcome these limitations. Here, we review the possible and necessary cell methods and techniques used for human hair follicle regeneration and the restoration of hair follicle cell inductivity in culture. |
| format | Article |
| id | doaj-art-1dcaa2582cbd4bf8a8ed4ecdf906b5af |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-12-01 |
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| series | Cells |
| spelling | doaj-art-1dcaa2582cbd4bf8a8ed4ecdf906b5af2025-01-10T13:16:14ZengMDPI AGCells2073-44092024-12-01141710.3390/cells14010007Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to OvercomeOns Ben Hamida0Moon Kyu Kim1Young Kwan Sung2Min Kyu Kim3Mi Hee Kwack4Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of KoreaDepartment of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of KoreaDepartment of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of KoreaDepartment of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of KoreaDepartment of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of KoreaThe hair follicle is a complex of mesenchymal and epithelial cells acquiring different properties and characteristics responsible for fulfilling its inductive and regenerative role. The epidermal and dermal crosstalk induces morphogenesis and maintains hair follicle cycling properties. The hair follicle is enriched with pluripotent stem cells, where dermal papilla (DP) cells and dermal sheath (DS) cells constitute the dermal compartment and the epithelial stem cells existing in the bulge region exert their regenerative role by mediating the epithelial–mesenchymal interaction (EMI). Many studies have developed and focused on various methods to optimize the EMI through in vivo and in vitro approaches for hair regeneration. The culturing of human hair mesenchymal cells resulted in the loss of trichogenicity and inductive properties of DP cells, limiting their potential application in de novo hair follicle generation in vivo. Epithelial stem cells derived from human hair follicles are challenging to isolate and culture, making it difficult to obtain enough cells for hair regeneration purposes. Mesenchymal stem cells and epithelial stem cells derived from human hair follicles lose their ability to form hair follicles during culture, limiting the study of hair follicle formation in vivo. Therefore, many attempts and methods have been developed to overcome these limitations. Here, we review the possible and necessary cell methods and techniques used for human hair follicle regeneration and the restoration of hair follicle cell inductivity in culture.https://www.mdpi.com/2073-4409/14/1/7human hair follicle regenerationdermal papilla cellsdermal sheath cellsepithelial stem cells |
| spellingShingle | Ons Ben Hamida Moon Kyu Kim Young Kwan Sung Min Kyu Kim Mi Hee Kwack Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome Cells human hair follicle regeneration dermal papilla cells dermal sheath cells epithelial stem cells |
| title | Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome |
| title_full | Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome |
| title_fullStr | Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome |
| title_full_unstemmed | Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome |
| title_short | Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome |
| title_sort | hair regeneration methods using cells derived from human hair follicles and challenges to overcome |
| topic | human hair follicle regeneration dermal papilla cells dermal sheath cells epithelial stem cells |
| url | https://www.mdpi.com/2073-4409/14/1/7 |
| work_keys_str_mv | AT onsbenhamida hairregenerationmethodsusingcellsderivedfromhumanhairfolliclesandchallengestoovercome AT moonkyukim hairregenerationmethodsusingcellsderivedfromhumanhairfolliclesandchallengestoovercome AT youngkwansung hairregenerationmethodsusingcellsderivedfromhumanhairfolliclesandchallengestoovercome AT minkyukim hairregenerationmethodsusingcellsderivedfromhumanhairfolliclesandchallengestoovercome AT miheekwack hairregenerationmethodsusingcellsderivedfromhumanhairfolliclesandchallengestoovercome |