Identification of deleterious non-synonymous single nucleotide polymorphisms in the mRNA decay activator ZFP36L2

Identification of deleterious non-synonymous single nucleotide polymorphisms in the mRNA decay activator ZFP36L2

More than 4,000 single nucleotide polymorphisms (SNP) variants have been identified in the human ZFP36L2 gene, however only a few have been studied in the context of protein function. The tandem zinc finger domain of ZFP36L2, an RNA binding protein, is the functional domain that binds to its target...

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Bibliographic Details
Main Authors: Betül Akçeşme, Hilal Hekimoğlu, Venkat R. Chirasani, Şeyma İş, Habibe Nur Atmaca, Justin M. Waldern, Silvia B.V. Ramos
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:RNA Biology
Subjects:
Zinc finger protein 36 like 2
non-synonymous single nucleotide polymorphisms (nsSNPs)
deleterious effect
RNA binding protein
Adenine Uridine Rich Elements (AREs)
Online Access:https://www.tandfonline.com/doi/10.1080/15476286.2024.2437590
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https://www.tandfonline.com/doi/10.1080/15476286.2024.2437590

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