Regulation of Blood–Brain Barrier Permeability via JNK Signaling Pathway: Mechanisms and Potential Therapeutic Strategies for Ischemic Stroke, Alzheimer’s Disease and Brain Tumors

Regulation of Blood–Brain Barrier Permeability via JNK Signaling Pathway: Mechanisms and Potential Therapeutic Strategies for Ischemic Stroke, Alzheimer’s Disease and Brain Tumors

Disruption of the blood–brain barrier (BBB) accompanies many brain diseases, including stroke, neurodegenerative diseases, and brain tumors, leading to swelling, increased neuroinflammation, and neuronal death. In recent years, it has become clear that the c-Jun N-terminal kinase (JNK) signaling pat...

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Bibliographic Details
Main Authors: Mark B. Plotnikov, Anna M. Anishchenko, Andrei I. Khlebnikov, Igor A. Schepetkin
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
Alzheimer’s disease
blood–brain barrier
brain tumor
ischemia/reperfusion
c-Jun N-terminal kinase (JNK)
JNK pathway
Online Access:https://www.mdpi.com/1420-3049/30/11/2353
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