The association between dietary creatine intake and cancer in U.S. adults: insights from NHANES 2007–2018
BackgroundCreatine has anti-inflammatory, antioxidant, and immunomodulatory effects. However, its impact on tumors remains uncertain.MethodsThis study used data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018 to investigate the relationship between dietary creati...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1460057/full |
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| author | Junhui Jiang Junhui Jiang Hu Zhao Jiong Chen Jiong Chen Junhao Du Weixiang Ni Weixiang Ni Baohua Zheng Junhong Wu Junhong Wu Chunhong Xiao |
| author_facet | Junhui Jiang Junhui Jiang Hu Zhao Jiong Chen Jiong Chen Junhao Du Weixiang Ni Weixiang Ni Baohua Zheng Junhong Wu Junhong Wu Chunhong Xiao |
| author_sort | Junhui Jiang |
| collection | DOAJ |
| description | BackgroundCreatine has anti-inflammatory, antioxidant, and immunomodulatory effects. However, its impact on tumors remains uncertain.MethodsThis study used data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018 to investigate the relationship between dietary creatine intake and cancer in American adults. A total of 25,879 participants aged 20 years and older were included, and their medical information, dietary creatine intake, and covariates were collected. Multiple logistic regression models were used to assess the relationships between age, dietary creatine intake, and cancer risk. Restricted cubic spline (RCS) analysis explored the nonlinear relationships between dietary creatine intake, age, and cancer prevalence.ResultsRCS analysis revealed a linear, negative association between dietary creatine intake and cancer risk. For each standard deviation (SD) increase in dietary creatine intake, cancer risk decreased by 5% (adjusted odds ratio (OR) = 0.95, 95% CI: 0.91–0.99, p = 0.025). This negative association was strongest among males (adjusted OR = 0.93, 95% CI: 0.88–0.99, p = 0.021) and overweight participants (adjusted OR = 0.92, 95% CI: 0.84–0.99, p = 0.044). Interaction results indicated specific age group effects. Further analysis showed that higher dietary creatine intake was significantly inversely associated with cancer risk among older adults (adjusted OR = 0.86, 95% CI: 0.77–0.97, p = 0.014). RCS analysis revealed a linear, positive correlation between age and cancer risk. For each SD increase in age, cancer risk increased by 3.27 times (adjusted OR = 3.27, 95% CI: 3.07–3.48, p < 0.001).ConclusionThese findings suggest that higher dietary creatine intake may reduce cancer risk in a nationally representative adult population. Further prospective studies are needed to clarify the relationship between dietary creatine intake and cancer risk. |
| format | Article |
| id | doaj-art-1dbe4483a35c4537825f4298a7f3c2b0 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-1dbe4483a35c4537825f4298a7f3c2b02025-01-10T05:10:31ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.14600571460057The association between dietary creatine intake and cancer in U.S. adults: insights from NHANES 2007–2018Junhui Jiang0Junhui Jiang1Hu Zhao2Jiong Chen3Jiong Chen4Junhao Du5Weixiang Ni6Weixiang Ni7Baohua Zheng8Junhong Wu9Junhong Wu10Chunhong Xiao11Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of General Surgery, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, ChinaDepartment of General Surgery, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, ChinaFuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of General Surgery, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, ChinaDepartment of General Surgery, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, ChinaFuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of General Surgery, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, ChinaDepartment of General Surgery, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, ChinaFuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of General Surgery, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, ChinaDepartment of General Surgery, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, ChinaBackgroundCreatine has anti-inflammatory, antioxidant, and immunomodulatory effects. However, its impact on tumors remains uncertain.MethodsThis study used data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018 to investigate the relationship between dietary creatine intake and cancer in American adults. A total of 25,879 participants aged 20 years and older were included, and their medical information, dietary creatine intake, and covariates were collected. Multiple logistic regression models were used to assess the relationships between age, dietary creatine intake, and cancer risk. Restricted cubic spline (RCS) analysis explored the nonlinear relationships between dietary creatine intake, age, and cancer prevalence.ResultsRCS analysis revealed a linear, negative association between dietary creatine intake and cancer risk. For each standard deviation (SD) increase in dietary creatine intake, cancer risk decreased by 5% (adjusted odds ratio (OR) = 0.95, 95% CI: 0.91–0.99, p = 0.025). This negative association was strongest among males (adjusted OR = 0.93, 95% CI: 0.88–0.99, p = 0.021) and overweight participants (adjusted OR = 0.92, 95% CI: 0.84–0.99, p = 0.044). Interaction results indicated specific age group effects. Further analysis showed that higher dietary creatine intake was significantly inversely associated with cancer risk among older adults (adjusted OR = 0.86, 95% CI: 0.77–0.97, p = 0.014). RCS analysis revealed a linear, positive correlation between age and cancer risk. For each SD increase in age, cancer risk increased by 3.27 times (adjusted OR = 3.27, 95% CI: 3.07–3.48, p < 0.001).ConclusionThese findings suggest that higher dietary creatine intake may reduce cancer risk in a nationally representative adult population. Further prospective studies are needed to clarify the relationship between dietary creatine intake and cancer risk.https://www.frontiersin.org/articles/10.3389/fnut.2024.1460057/fullcreatinecancerageNHANESnutrition |
| spellingShingle | Junhui Jiang Junhui Jiang Hu Zhao Jiong Chen Jiong Chen Junhao Du Weixiang Ni Weixiang Ni Baohua Zheng Junhong Wu Junhong Wu Chunhong Xiao The association between dietary creatine intake and cancer in U.S. adults: insights from NHANES 2007–2018 Frontiers in Nutrition creatine cancer age NHANES nutrition |
| title | The association between dietary creatine intake and cancer in U.S. adults: insights from NHANES 2007–2018 |
| title_full | The association between dietary creatine intake and cancer in U.S. adults: insights from NHANES 2007–2018 |
| title_fullStr | The association between dietary creatine intake and cancer in U.S. adults: insights from NHANES 2007–2018 |
| title_full_unstemmed | The association between dietary creatine intake and cancer in U.S. adults: insights from NHANES 2007–2018 |
| title_short | The association between dietary creatine intake and cancer in U.S. adults: insights from NHANES 2007–2018 |
| title_sort | association between dietary creatine intake and cancer in u s adults insights from nhanes 2007 2018 |
| topic | creatine cancer age NHANES nutrition |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1460057/full |
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