A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial properties
Bone graft absorption and infection are the major challenges to guided bone regeneration(GBR), yet the GBR membrane is neither osteogenic nor antibacterial. Hence, we followed sono-piezo therapy strategy by fabricating an electrospun membrane dispersed with boron nitride nanotubes. The PLLA/Gelatine...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004794 |
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| author | Keshi Zhu Ruixue Li Shi Yin Fei Yang Yang Sun Yixiao Xing Yiling Yang Wanjing Xu Youcheng Yu |
| author_facet | Keshi Zhu Ruixue Li Shi Yin Fei Yang Yang Sun Yixiao Xing Yiling Yang Wanjing Xu Youcheng Yu |
| author_sort | Keshi Zhu |
| collection | DOAJ |
| description | Bone graft absorption and infection are the major challenges to guided bone regeneration(GBR), yet the GBR membrane is neither osteogenic nor antibacterial. Hence, we followed sono-piezo therapy strategy by fabricating an electrospun membrane dispersed with boron nitride nanotubes. The PLLA/Gelatine/PDA@BNNT (PGBT) membrane has improved mechanical and biocompatible properties and generate piezovoltages of 130 mV when activated by ultrasound stimulation under 100 mW/cm2 without extra polarization. The PGBT with ultrasound is conducive to cellular osteogenesis, barrier function, and shows antibacterial rate of about 40 %. The rat cranial defect experiments revealed that PGBT with ultrasound could promote osteogenesis in-vivo and show great potentials for vertical bone defect repair. |
| format | Article |
| id | doaj-art-1dbbdc7ad6d84518a4557a89314242e6 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-1dbbdc7ad6d84518a4557a89314242e62025-01-17T04:52:09ZengElsevierMaterials Today Bio2590-00642025-02-0130101418A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial propertiesKeshi Zhu0Ruixue Li1Shi Yin2Fei Yang3Yang Sun4Yixiao Xing5Yiling Yang6Wanjing Xu7Youcheng Yu8Department of Stomatology, Zhongshan Hospital of Fudan University, Shanghai, ChinaDepartment of Stomatology, Xuhui Central Hospital, Shanghai, China; Department of Stomatology, Zhongshan Hospital of Fudan University, Shanghai, ChinaDepartment of Stomatology, Zhongshan Hospital of Fudan University, Shanghai, ChinaDepartment of Stomatology, Zhongshan Hospital of Fudan University, Shanghai, China; Department of Stomatology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, ChinaDepartment of Stomatology, Zhongshan Hospital of Fudan University, Shanghai, ChinaDepartment of Stomatology, Zhongshan Hospital of Fudan University, Shanghai, ChinaDepartment of Stomatology, Zhongshan Hospital of Fudan University, Shanghai, ChinaDepartment of Stomatology, Zhongshan Hospital of Fudan University, Shanghai, ChinaDepartment of Stomatology, Zhongshan Hospital of Fudan University, Shanghai, China; Department of Stomatology, Xuhui Central Hospital, Shanghai, China; Corresponding author. Department of Stomatology, Zhongshan Hospital of Fudan University, Shanghai, ChinaBone graft absorption and infection are the major challenges to guided bone regeneration(GBR), yet the GBR membrane is neither osteogenic nor antibacterial. Hence, we followed sono-piezo therapy strategy by fabricating an electrospun membrane dispersed with boron nitride nanotubes. The PLLA/Gelatine/PDA@BNNT (PGBT) membrane has improved mechanical and biocompatible properties and generate piezovoltages of 130 mV when activated by ultrasound stimulation under 100 mW/cm2 without extra polarization. The PGBT with ultrasound is conducive to cellular osteogenesis, barrier function, and shows antibacterial rate of about 40 %. The rat cranial defect experiments revealed that PGBT with ultrasound could promote osteogenesis in-vivo and show great potentials for vertical bone defect repair.http://www.sciencedirect.com/science/article/pii/S2590006424004794 |
| spellingShingle | Keshi Zhu Ruixue Li Shi Yin Fei Yang Yang Sun Yixiao Xing Yiling Yang Wanjing Xu Youcheng Yu A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial properties Materials Today Bio |
| title | A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial properties |
| title_full | A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial properties |
| title_fullStr | A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial properties |
| title_full_unstemmed | A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial properties |
| title_short | A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial properties |
| title_sort | novel ultrasound driven piezoelectric gbr membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti bacterial properties |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004794 |
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