MicroRNA-668 alleviates renal fibrosis through PPARα/PGC-1α pathway

MicroRNA-668 alleviates renal fibrosis through PPARα/PGC-1α pathway

Abstract Background The involvement of microRNA-668 (miR-668) in the onset and progression of renal fibrosis remains unclear. To this end, we aimed to explore the relevant mechanism of miR-668 in renal fibrosis. Methods C57BL/6 J male mice were randomly divided into sham-operated, unilateral uretera...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xinran Wang, Zhoupeng Gu, Yan Huang, Jingyan Wang, Shiqi Tang, Xinyu Yang, Jianwen Wang
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Series:	European Journal of Medical Research
Subjects:	MicroRNA-668 PPARα PGC-1α Renal fibrosis Fenofibrate
Online Access:	https://doi.org/10.1186/s40001-024-02248-x
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

1-Bromopropane induces mitochondrial damage and lipid metabolism imbalance in respiratory epithelial cells through the PGC-1α/PPARα pathway
by: Qiuyun Wu, et al.
Published: (2025-01-01)

ADRB2 serves as a novel biomarker and attenuates alcoholic hepatitis via the SIRT1/PGC-1α/PPARα pathway: integration of WGCNA, machine learning and experimental validation
by: Li Song, et al.
Published: (2024-11-01)

Triiodothyronine activates THRβ to promote PGC1α expression alleviating PQ-induced pulmonary fibrosis
by: Wenbo Chen, et al.
Published: (2025-01-01)

Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway
by: Baolong Li, et al.
Published: (2025-01-01)

Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential
by: Mi-bo Tang, et al.
Published: (2025-02-01)

Fenofibrate as an Adjunct Therapy for Ulcerative Colitis: Targeting Inflammation via SIRT1, NLRP3, and AMPK Pathways: A Randomized Controlled Pilot Study
by: Alarfaj SJ, et al.
Published: (2024-11-01)

PGC-1α Promotes mitochondrial biosynthesis and energy metabolism of goose fatty liver
by: Jiahui Li, et al.
Published: (2025-01-01)

CTRP6‐mediated cardiac protection in heart failure via the AMPK/SIRT1/PGC‐1α signalling pathway
by: Tingting Fan, et al.
Published: (2024-12-01)

α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation
by: Haowei Wang, et al.
Published: (2025-01-01)

PGC-1α通过上调SIRT3表达发挥心肌保护作用
Published: (2016-01-01)

Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK/PGC1- α/Irisin pathway
by: Haijuan Liu, et al.
Published: (2025-01-01)

An AMP‐activated protein kinase‐PGC‐1α axis mediates metabolic plasticity in glioblastoma
by: Benedikt Sauer, et al.
Published: (2024-11-01)

Bilirubin, a hepatoprotective agent that activates SIRT1, PGC-1α, and PPAR-α, while inhibiting NF-κB in rats with metabolic-associated fatty liver disease
by: Motahareh Taghizadeh, et al.
Published: (2024-11-01)

SIRT1/PGC-1α-mediated mitophagy participates the improvement roles of BMAL1 in podocytes injury in diabetic nephropathy: evidences from in vitro experiments
by: Yanxia Rui, et al.
Published: (2025-01-01)

Pemafibrate Induces a Low Level of PPARα Agonist-Stimulated mRNA Expression of ANGPTL4 in ARPE19 Cell
by: Hiroshi Ohguro, et al.
Published: (2024-12-01)

A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα
by: Alessandra Ammazzalorso, et al.
Published: (2024-11-01)

Cell-free supernatant of Levilactobacillus brevis (RAMULAB51) from coconut inflorescence sap (Neera) enhances glucose uptake and PPAR-γ in 3T3-L1 adipocytes and inhibits α-glucosidase and α-amylase
by: Chandana Kumari V B, et al.
Published: (2024-12-01)

Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC‐1α‐mediated Transcriptional Coactivation
by: Chen Duan, et al.
Published: (2024-12-01)

The effect of eight weeks of high-intensity interval training vs. continuous training on serum Irisin levels and expression of skeletal muscle PGC-1α gene in male rats with metabolic syndrome
by: Zohreh Borhani Kakhki, et al.
Published: (2022-04-01)

Antidiabetic Effect of Dihydrobetulonic Acid Derivatives as Pparα/γ Agonists
by: Mikhail V. Khvostov, et al.
Published: (2024-12-01)

Deletion of lymphotoxin-β receptor (LTβR) protects against acute kidney injury by PPARα pathway
by: Zufeng Wang, et al.
Published: (2024-12-01)

Golden Tomato Juice Enhances Hepatic PPAR-α Expression, Mitigates Metabolic Dysfunctions and Influences Redox Balance in a High-Fat-Diet Rat Model
by: Danila Di Majo, et al.
Published: (2024-10-01)

PPARα suppresses growth of hepatocellular carcinoma in a high-fat diet context by reducing neutrophil extracellular trap release
by: Banglun Pan, et al.
Published: (2025-01-01)

Pear pomace soluble dietary fiber suppresses fat deposition in high fat diet-fed mice by regulating the ADPN-AMPK/PPAR-α signaling pathway
by: Jinrong Zhao, et al.
Published: (2024-11-01)

Alpiniae oxyphyllae Fructus ameliorates renal lipid accumulation in diabetic kidney disease via activating PPARα
by: Zi-Jie Yan, et al.
Published: (2025-01-01)

α-spectrum estimation method for ARMA SαS process based on FLOC
by: WANG Shou-yong1, et al.
Published: (2007-01-01)

Biology and Management of the Asian Citrus Psyllid, Diaphorina citri Kuwayama, in Florida Citrus
by: Michael E. Rogers, et al.
Published: (2007-04-01)

Biology and Management of the Asian Citrus Psyllid, Diaphorina citri Kuwayama, in Florida Citrus
by: Michael E. Rogers, et al.
Published: (2007-04-01)

AMPK regulates the maintenance and remodelling of the neuromuscular junction
by: Sean Y. Ng, et al.
Published: (2025-01-01)

How PPAR-alpha mediated inflammation may affect the pathophysiology of chronic kidney disease
by: Sepiso K. Masenga, et al.
Published: (2025-01-01)

Vida Saludable para Personas de Edad: ¡Use Sus Medicinas Con Prudencia!
by: Paulina Wittkowsky
Published: (2004-08-01)

Vida Saludable para Personas de Edad: ¡Use Sus Medicinas Con Prudencia!
by: Paulina Wittkowsky
Published: (2004-08-01)

HB H DISEASE CAUSED BY UNIPARENTAL DISOMY: FIRST REPORT OF THE αT-SAUDIΑ MUTATION IN THE CHINESE POPULATION
by: Ge Wang, et al.
Published: (2024-08-01)

Translational research from bioinformatics to animal studies: Exploring gene expression and muscle health in COPD through selenium nanoparticles and exercise
by: Mahdi Bakhshi, et al.
Published: (2024-06-01)

PPARGC1A regulates transcriptional control of mitochondrial biogenesis in early bovine embryos
by: Muhammad Idrees, et al.
Published: (2025-01-01)

Astragalin improved mitochondrial function through AMPK/PGC-1α pathway and alleviated renal injury in diabetic nephropathy
by: Yi Luo, et al.
Published: (2024-11-01)

Alpha-Synuclein Effects on Mitochondrial Quality Control in Parkinson’s Disease
by: Lydia Shen, et al.
Published: (2024-12-01)

Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice
by: Sae Nishihara, et al.
Published: (2024-11-01)

Amelioration of High Fructose Diet-Induced Insulin Resistance, Hyperuricemia, and Liver Oxidative Stress by Combined Use of Selective Agonists of PPAR-α and PPAR-γ in Rats
by: Mahmoud M. Farag, et al.
Published: (2020-04-01)

Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting α-amylase, and α-glucosidase: synthesis, molecular docking, and ADMET studies
by: Nirvana A. Gohar, et al.
Published: (2024-12-01)