RNA nanostructures for targeted drug delivery and imaging
The RNA molecule plays a pivotal role in many biological processes by relaying genetic information, regulating gene expression, and serving as molecular machines and catalyzers. This inherent versatility of RNA has fueled significant advancements in the field of RNA nanotechnology, driving the engin...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2024.2328440 |
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| _version_ | 1846127941869633536 |
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| author | Laura Teodori Marjan Omer Jørgen Kjems |
| author_facet | Laura Teodori Marjan Omer Jørgen Kjems |
| author_sort | Laura Teodori |
| collection | DOAJ |
| description | The RNA molecule plays a pivotal role in many biological processes by relaying genetic information, regulating gene expression, and serving as molecular machines and catalyzers. This inherent versatility of RNA has fueled significant advancements in the field of RNA nanotechnology, driving the engineering of complex nanoscale architectures toward biomedical applications, including targeted drug delivery and bioimaging. RNA polymers, serving as building blocks, offer programmability and predictability of Watson-Crick base pairing, as well as non-canonical base pairing, for the construction of nanostructures with high precision and stoichiometry. Leveraging the ease of chemical modifications to protect the RNA from degradation, researchers have developed highly functional and biocompatible RNA architectures and integrated them into preclinical studies for the delivery of payloads and imaging agents. This review offers an educational introduction to the use of RNA as a biopolymer in the design of multifunctional nanostructures applied to targeted delivery in vivo, summarizing physical and biological barriers along with strategies to overcome them. Furthermore, we highlight the most recent progress in the development of both small and larger RNA nanostructures, with a particular focus on imaging reagents and targeted cancer therapeutics in pre-clinical models and provide insights into the prospects of this rapidly evolving field. |
| format | Article |
| id | doaj-art-1d8feccf03d64ba78314c62d4b2d1973 |
| institution | Kabale University |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-1d8feccf03d64ba78314c62d4b2d19732024-12-11T07:19:50ZengTaylor & Francis GroupRNA Biology1547-62861555-85842024-12-0121139140910.1080/15476286.2024.2328440RNA nanostructures for targeted drug delivery and imagingLaura Teodori0Marjan Omer1Jørgen Kjems2Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C, DenmarkInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C, DenmarkInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C, DenmarkThe RNA molecule plays a pivotal role in many biological processes by relaying genetic information, regulating gene expression, and serving as molecular machines and catalyzers. This inherent versatility of RNA has fueled significant advancements in the field of RNA nanotechnology, driving the engineering of complex nanoscale architectures toward biomedical applications, including targeted drug delivery and bioimaging. RNA polymers, serving as building blocks, offer programmability and predictability of Watson-Crick base pairing, as well as non-canonical base pairing, for the construction of nanostructures with high precision and stoichiometry. Leveraging the ease of chemical modifications to protect the RNA from degradation, researchers have developed highly functional and biocompatible RNA architectures and integrated them into preclinical studies for the delivery of payloads and imaging agents. This review offers an educational introduction to the use of RNA as a biopolymer in the design of multifunctional nanostructures applied to targeted delivery in vivo, summarizing physical and biological barriers along with strategies to overcome them. Furthermore, we highlight the most recent progress in the development of both small and larger RNA nanostructures, with a particular focus on imaging reagents and targeted cancer therapeutics in pre-clinical models and provide insights into the prospects of this rapidly evolving field.https://www.tandfonline.com/doi/10.1080/15476286.2024.2328440RNA nanostructuresRNA therapeuticstargeted drug deliverybioimagingaptamerstumour targeting |
| spellingShingle | Laura Teodori Marjan Omer Jørgen Kjems RNA nanostructures for targeted drug delivery and imaging RNA Biology RNA nanostructures RNA therapeutics targeted drug delivery bioimaging aptamers tumour targeting |
| title | RNA nanostructures for targeted drug delivery and imaging |
| title_full | RNA nanostructures for targeted drug delivery and imaging |
| title_fullStr | RNA nanostructures for targeted drug delivery and imaging |
| title_full_unstemmed | RNA nanostructures for targeted drug delivery and imaging |
| title_short | RNA nanostructures for targeted drug delivery and imaging |
| title_sort | rna nanostructures for targeted drug delivery and imaging |
| topic | RNA nanostructures RNA therapeutics targeted drug delivery bioimaging aptamers tumour targeting |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2024.2328440 |
| work_keys_str_mv | AT laurateodori rnananostructuresfortargeteddrugdeliveryandimaging AT marjanomer rnananostructuresfortargeteddrugdeliveryandimaging AT jørgenkjems rnananostructuresfortargeteddrugdeliveryandimaging |