Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up study
Background: The association between inflammatory bowel disease (IBD) activity and poor sleep quality is reported. However, most research subjectively investigated this issue and lacked long-term follow-up. Objectives: Our study aimed to investigate the prevalence of sleep disturbance in IBD patients...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/17562848241311142 |
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| author | Thanaboon Chaemsupaphan Chawanont Pimolsri Nichcha Subdee Phutthaphorn Phaophu Marianee Salaemae Parinya Permpim Lakkana Thongchot Kamonnet Wannasewok Wattanachai Chotinaiwattarakul Julajak Limsrivilai |
| author_facet | Thanaboon Chaemsupaphan Chawanont Pimolsri Nichcha Subdee Phutthaphorn Phaophu Marianee Salaemae Parinya Permpim Lakkana Thongchot Kamonnet Wannasewok Wattanachai Chotinaiwattarakul Julajak Limsrivilai |
| author_sort | Thanaboon Chaemsupaphan |
| collection | DOAJ |
| description | Background: The association between inflammatory bowel disease (IBD) activity and poor sleep quality is reported. However, most research subjectively investigated this issue and lacked long-term follow-up. Objectives: Our study aimed to investigate the prevalence of sleep disturbance in IBD patients across disease activity and evaluate the long-term correlation between disease activity, sleep quality, and quality of life. Design: This prospective observational study assessed sleep quality in patients with IBD. Methods: Patients with IBD were categorized into groups based on clinical activity scores. The sleep questionnaire (Pittsburgh Sleep Quality Index (PSQI)) and IBD questionnaire (IBDQ) were evaluated monthly for 12 months. Seven-day sleep data from wrist actigraphy (Actiwatch ® ) were collected at initiation and completion. Longitudinal correlation was analyzed. Results: A total of 98 participants were enrolled, consisting of 68 remission, 21 mild, and 9 moderate-to-severe disease activities. At baseline, 60% of participants demonstrated poor sleep quality, defined by a PSQI of >5. The group with greater disease severity reported numerically poorer sleep quality; however, this difference was not statistically significant. On actigraphy, there was no statistically significant difference in sleep latency, wake after sleep onset, or sleep efficiency between the groups. During follow-up, 90 patients responded to questionnaires. The mean PSQI decreased from 7.1 to 5.4 among 22 patients whose active disease transitioned to remission ( p < 0.001). However, the score did not change in 11 patients with remission and developed disease flare (5.9–5.8). The mean PSQI was 7.7 and 6.3 in 4 and 53 patients whose disease remained active and inactive during follow-up, respectively. Multivariable longitudinal analysis revealed that PSQI was independently associated with active disease (odds ratio = 1.22) and inversely associated with IBDQ (β = −2.23). Sleep latency was evaluated by PSQI, and actigraphy was significantly correlated. Conclusions: Patients with IBD frequently experience poor sleep quality, which significantly correlates with active disease and worse quality of life longitudinally. |
| format | Article |
| id | doaj-art-1d8a76b07aac4af1abc6fa3629f7d9ec |
| institution | Kabale University |
| issn | 1756-2848 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj-art-1d8a76b07aac4af1abc6fa3629f7d9ec2025-01-03T16:03:39ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482025-01-011810.1177/17562848241311142Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up studyThanaboon ChaemsupaphanChawanont PimolsriNichcha SubdeePhutthaphorn PhaophuMarianee SalaemaeParinya PermpimLakkana ThongchotKamonnet WannasewokWattanachai ChotinaiwattarakulJulajak LimsrivilaiBackground: The association between inflammatory bowel disease (IBD) activity and poor sleep quality is reported. However, most research subjectively investigated this issue and lacked long-term follow-up. Objectives: Our study aimed to investigate the prevalence of sleep disturbance in IBD patients across disease activity and evaluate the long-term correlation between disease activity, sleep quality, and quality of life. Design: This prospective observational study assessed sleep quality in patients with IBD. Methods: Patients with IBD were categorized into groups based on clinical activity scores. The sleep questionnaire (Pittsburgh Sleep Quality Index (PSQI)) and IBD questionnaire (IBDQ) were evaluated monthly for 12 months. Seven-day sleep data from wrist actigraphy (Actiwatch ® ) were collected at initiation and completion. Longitudinal correlation was analyzed. Results: A total of 98 participants were enrolled, consisting of 68 remission, 21 mild, and 9 moderate-to-severe disease activities. At baseline, 60% of participants demonstrated poor sleep quality, defined by a PSQI of >5. The group with greater disease severity reported numerically poorer sleep quality; however, this difference was not statistically significant. On actigraphy, there was no statistically significant difference in sleep latency, wake after sleep onset, or sleep efficiency between the groups. During follow-up, 90 patients responded to questionnaires. The mean PSQI decreased from 7.1 to 5.4 among 22 patients whose active disease transitioned to remission ( p < 0.001). However, the score did not change in 11 patients with remission and developed disease flare (5.9–5.8). The mean PSQI was 7.7 and 6.3 in 4 and 53 patients whose disease remained active and inactive during follow-up, respectively. Multivariable longitudinal analysis revealed that PSQI was independently associated with active disease (odds ratio = 1.22) and inversely associated with IBDQ (β = −2.23). Sleep latency was evaluated by PSQI, and actigraphy was significantly correlated. Conclusions: Patients with IBD frequently experience poor sleep quality, which significantly correlates with active disease and worse quality of life longitudinally.https://doi.org/10.1177/17562848241311142 |
| spellingShingle | Thanaboon Chaemsupaphan Chawanont Pimolsri Nichcha Subdee Phutthaphorn Phaophu Marianee Salaemae Parinya Permpim Lakkana Thongchot Kamonnet Wannasewok Wattanachai Chotinaiwattarakul Julajak Limsrivilai Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up study Therapeutic Advances in Gastroenterology |
| title | Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up study |
| title_full | Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up study |
| title_fullStr | Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up study |
| title_full_unstemmed | Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up study |
| title_short | Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up study |
| title_sort | poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease a long term follow up study |
| url | https://doi.org/10.1177/17562848241311142 |
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