Synthesis, Spectroscopic Characterization, Structural Analysis, and Evaluation of Anti-Tumor, Antimicrobial, and Antibiofilm Activities of Halogenoaminopyrazoles Derivatives

Synthesis, Spectroscopic Characterization, Structural Analysis, and Evaluation of Anti-Tumor, Antimicrobial, and Antibiofilm Activities of Halogenoaminopyrazoles Derivatives

New haloaminopyrazole derivatives differing in the number of pyrazole nuclei <b>4a</b>–<b>f</b> and <b>5a</b>–<b>e</b>, respectively, were synthesized and characterized by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, IR, UV-Vis, and e...

Full description

Saved in:

Bibliographic Details
Main Authors:	Christina Zalaru, Florea Dumitrascu, Constantin Draghici, Marilena Ferbinteanu, Isabela Tarcomnicu, Maria Marinescu, Zenovia Moldovan, George Mihai Nitulescu, Rodica Tatia, Marcela Popa
Format:	Article
Language:	English
Published:	MDPI AG 2024-11-01
Series:	Antibiotics
Subjects:	pyrazoles heterocyclic molecules cytotoxicity anti-tumor antimicrobial biofilm formation
Online Access:	https://www.mdpi.com/2079-6382/13/12/1119
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis of Perfluoroalkylated Pyrazoles from α-Perfluoroalkenylated Aldehydes
by: Lennart Bunnemann, et al.
Published: (2024-10-01)

Novel Ethyl 1,5-Disubstituted-1H-Pyrazole-3-Carboxylates as a New Class of Antimicrobial Agents
by: Radwan Awwad A., et al.
Published: (2014-09-01)

2-([1,1′-Biphenyl]-4-yl)-5-[(<i>E</i>)-2-(3-methoxy-1-phenyl-1<i>H</i>-pyrazol-4-yl)ethenyl]-3,3-dimethyl-3<i>H</i>-indole
by: Gabrielė Varvuolytė, et al.
Published: (2024-11-01)

Non-nucleophilic base promoted synthesis of azo-linked oxazolone-pyrazole hybrids: Antimicrobial, antitubercular, anticancer evaluations and in-silico modeling insights
by: Bonny Y. Patel, et al.
Published: (2024-12-01)

Synthesis and antitumor activity of some novel thiophene, pyrimidine, coumarin, pyrazole and pyridine derivatives
by: Albratty Mohammed, et al.
Published: (2017-03-01)

Direct ring fluorination of 3-substituted 5-(1,3-dioxane) acetal isoxazoles: application to the formal synthesis of a bioactive fluorinated isoxazole
by: Bacheley, Lucas, et al.
Published: (2024-02-01)

Photocatalysed eosin Y mediated synthesis of biologically potent 4 (3H)-quinazolinone
by: Pravin Kumar Singh, et al.
Published: (2024-12-01)

An Overview of Pyrazole-Tetrazole-Based Hybrid Compounds: Synthesis Methods, Biological Activities and Energetic Properties
by: Mounir Cherfi, et al.
Published: (2024-12-01)

Synthesis and selective Cu(II) complexation of lower rim substituted thiacalixarenes containing pyrazole fragments
by: Valeriy Kalinin, et al.
Published: (2024-11-01)

A new polyazomethine-based pyrazole moiety and its reinforced nanocomposites @ ZnO for antimicrobial applications
by: Aqilah A. Hakami, et al.
Published: (2024-12-01)

Pyrazole derivatives as antileishmanial agents: Biological evaluation, molecular docking study, DFT analysis and ADME prediction
by: Razieh Sabet, et al.
Published: (2024-12-01)

Targeting Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2): Latest Insights on Synthetic Strategies
by: Carolina S. Marques, et al.
Published: (2024-11-01)

5,5’-Selenobis(1-benzyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde)
by: Emeline Grosjean, et al.
Published: (2024-11-01)

3aH,4H,5H,8H,9H,9aH-Cycloocta[d][1,3]dioxole-2-thione
by: Dieter Schollmeyer, et al.
Published: (2024-11-01)

New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract
by: María I. Osella, et al.
Published: (2025-01-01)

Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review
by: Dana M. Odeh, et al.
Published: (2025-01-01)

Synthesis and evaluation of the antifungal activity of 5-hydroxy-3-phenyl-1H-pyrazole-1-carbothioamide for use in the oral environment
by: Hossein Amin Zadeh, et al.
Published: (2024-03-01)

One-pot green synthesis, biological evaluation, and in silico study of pyrazole derivatives obtained from chalcones
by: Ghazaryan Emma, et al.
Published: (2024-11-01)

Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
by: Yulia Volkova, et al.
Published: (2023-11-01)

A simple route to 7-substituted Quinolin-2(1H)-ones from Meta-substituted anilines
by: Marisol Varela Ausec, et al.
Published: (2025-03-01)

Synthesis of and theoretical research on some azine derivatives and investigation of their antimicrobial activities
by: Aytaç Sertan
Published: (2024-01-01)

The Role of Hydrogen Bond Interactions in Crystal Formation of Pyrrolo-Azines Alcohols
by: Marcel Mirel Popa, et al.
Published: (2025-01-01)

Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives
by: Basma T. Abd-Elhalim, et al.
Published: (2025-02-01)

Synthesis of pyrazole and pyrazoline derivatives of β-ionone: Exploring anti-inflammatory potential, cytotoxicity, and molecular docking insights
by: Monika Sihag, et al.
Published: (2024-12-01)

Recent Advances in the Synthesis of Cyclic Sulfone Compounds with Potential Biological Activity
by: Hong-Li Huang, et al.
Published: (2024-12-01)

A review of leishmaniasis: current knowledge and future directions of heterocyclic molecules
by: Tejaswini Masne, et al.
Published: (2024-09-01)

Synthetic strategy toward furyl- and benzofuryl-containing building blocks for organic materials
by: Diana A. Eshmemet’eva, et al.
Published: (2022-07-01)

Synthesis, Identification, and anti-cancer Evaluation of Some heterocyclic Chitosan-Thiosemicarbazones compounds and their nickle (II) complexes
by: Mohsin Omar Mohammed, et al.
Published: (2024-12-01)

Recent Advances in Sequentially Pd-Catalyzed One-Pot Syntheses of Heterocycles
by: Maryna M. Kornet, et al.
Published: (2024-11-01)

Organobase catalyzed synthesis of pyranopyrazoles with X-ray crystallography, docking and ADME studies
by: Md. Musawwer Khan, et al.
Published: (2024-12-01)

Synthesis and Characterization of 4-chloro-N'-2-(3,3-dimethyl-1,3-dihydro-2H-benzo[f]indol-2-ylidene)-3-oxopropylidene) benzohydrazonamide and 3-(4-chlorophenyl)-1H-1,2,4-triazole
by: Zahra Ali Nasir, et al.
Published: (2023-10-01)

Recent Advances in the Application of 2‐Aminobenzothiazole to the Multicomponent Synthesis of Heterocycles
by: Ramin Javahershenas, et al.
Published: (2024-11-01)

Experimental and computational approach on the corrosion inhibition properties of two newly pyrazole derivatives on carbon steel in acid medium
by: Nawal Setti, et al.
Published: (2025-01-01)

Exertion in Kangoo Jumps Aerobic: Evaluation and Interpretation Using Spectroscopic Technique Determinations
by: Cristina Popa, et al.
Published: (2013-01-01)

Building Up a Hexacopper(II)-Pyrazolate/Oxamate Magnetic Complex with Rare Ethane-1,2-Dioxide (–OCH<sub>2</sub>CH<sub>2</sub>O–) as a Bridge Between Copper(II) Units
by: Willian X. C. Oliveira, et al.
Published: (2024-11-01)

The synthesis of 5-amino-3-aryl-1H-pyrazole-4-carbonitriles based on hydrazines and benzhydrazides under ultrasonic activation conditions
by: Meshcheryakova, Anna A., et al.
Published: (2024-09-01)

Synthesis of extended fluorinated tripeptides based on the tetrahydropyridazine scaffold
by: Thierry Milcent, et al.
Published: (2024-12-01)

A New Synthesis of Polyheterocyclic Compounds Containing Nitrogen and Boron Atoms
by: Victor Yu Kirsanov, et al.
Published: (2023-11-01)

Pharmaceutical perspectives of thiazole analogues: An overview
by: Archana R. Patil, et al.
Published: (2024-12-01)

The role of flavonoids in mitigating food originated heterocyclic aromatic amines that concerns human wellness
by: Hui Teng, et al.
Published: (2023-07-01)