The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis
BackgroundThe body of research on tumor-infiltrating lymphocytes (TILs) is expanding rapidly; yet, a comprehensive analysis of related publications has been notably absent.ObjectiveThis study utilizes bibliometric methodologies to identify emerging research hotspots and to map the distribution of tu...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1511866/full |
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| author | Beibei Wu Beibei Wu Beibei Wu Ding Luo Ding Luo Xuejie Wang Xuejie Wang Chen Qiao Chen Qiao Rui Li Jian Liu Jian Liu |
| author_facet | Beibei Wu Beibei Wu Beibei Wu Ding Luo Ding Luo Xuejie Wang Xuejie Wang Chen Qiao Chen Qiao Rui Li Jian Liu Jian Liu |
| author_sort | Beibei Wu |
| collection | DOAJ |
| description | BackgroundThe body of research on tumor-infiltrating lymphocytes (TILs) is expanding rapidly; yet, a comprehensive analysis of related publications has been notably absent.ObjectiveThis study utilizes bibliometric methodologies to identify emerging research hotspots and to map the distribution of tumor-infiltrating lymphocyte research.MethodsLiterature from the Web of Science database was analyzed and visualized using VOSviewer, CiteSpace, Scimago Graphica, R-bibliometrix, and R packages.ResultsResearch on tumor-infiltrating lymphocytes began in 1975 and has experienced significant growth, particularly after 2015. Leading contributors include the United States, the National Cancer Institute, the journal Cancer Immunology Immunotherapy, and researcher Steven A. Rosenberg. Other prominent contributors include China, the National Institutes of Health, researcher Roberto Salgado, and the Journal of Immunology. Prominent institutions in the USA and Europe occupy central roles within collaborative networks. Financial support plays a pivotal role in driving research advancements. Keyword clustering analysis reveals four primary knowledge domains: adoptive cell therapy; the prognostic value of TILs; PD-1/PD-L1 and TILs; and prognostic studies of TILs across various cancers. Keyword and reference analyses further indicate that “adoptive cell therapy,” “the prognostic value of TILs,” and “immune checkpoint inhibitors and TILs” are central themes in current and future research. Combination therapies; tumor neoantigens; gene editing; dominant population selection of TILs therapy; TILs in Tumor microenvironment; emerging predictive biomarkers; TILs in predicting the efficacy of neoadjuvant chemotherapy and immunotherapy; the relationship between TILs and PD-L1; TIL-based patient stratification; tertiary lymphoid structures; and TIL evaluation through digital pathology and artificial intelligence are identified as key areas of interest.ConclusionsThis analysis highlights the increasing academic focus on tumor-infiltrating lymphocyte research and identifies key recent themes in the field such as prognostic value of TILs, personalized treatments, and combination therapies. |
| format | Article |
| id | doaj-art-1d85b49938e64c839513a2f8626accfd |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-1d85b49938e64c839513a2f8626accfd2025-01-06T06:58:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15118661511866The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysisBeibei Wu0Beibei Wu1Beibei Wu2Ding Luo3Ding Luo4Xuejie Wang5Xuejie Wang6Chen Qiao7Chen Qiao8Rui Li9Jian Liu10Jian Liu11Beijing Traditional Chinese Medicine Office for Cancer Prevention and Control, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaDepartment of Information, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaDepartment of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaBeijing Traditional Chinese Medicine Office for Cancer Prevention and Control, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaDepartment of Information, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaBeijing Traditional Chinese Medicine Office for Cancer Prevention and Control, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaDepartment of Information, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaBeijing Traditional Chinese Medicine Office for Cancer Prevention and Control, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaDepartment of Information, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaDepartment of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaBeijing Traditional Chinese Medicine Office for Cancer Prevention and Control, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaDepartment of Information, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, ChinaBackgroundThe body of research on tumor-infiltrating lymphocytes (TILs) is expanding rapidly; yet, a comprehensive analysis of related publications has been notably absent.ObjectiveThis study utilizes bibliometric methodologies to identify emerging research hotspots and to map the distribution of tumor-infiltrating lymphocyte research.MethodsLiterature from the Web of Science database was analyzed and visualized using VOSviewer, CiteSpace, Scimago Graphica, R-bibliometrix, and R packages.ResultsResearch on tumor-infiltrating lymphocytes began in 1975 and has experienced significant growth, particularly after 2015. Leading contributors include the United States, the National Cancer Institute, the journal Cancer Immunology Immunotherapy, and researcher Steven A. Rosenberg. Other prominent contributors include China, the National Institutes of Health, researcher Roberto Salgado, and the Journal of Immunology. Prominent institutions in the USA and Europe occupy central roles within collaborative networks. Financial support plays a pivotal role in driving research advancements. Keyword clustering analysis reveals four primary knowledge domains: adoptive cell therapy; the prognostic value of TILs; PD-1/PD-L1 and TILs; and prognostic studies of TILs across various cancers. Keyword and reference analyses further indicate that “adoptive cell therapy,” “the prognostic value of TILs,” and “immune checkpoint inhibitors and TILs” are central themes in current and future research. Combination therapies; tumor neoantigens; gene editing; dominant population selection of TILs therapy; TILs in Tumor microenvironment; emerging predictive biomarkers; TILs in predicting the efficacy of neoadjuvant chemotherapy and immunotherapy; the relationship between TILs and PD-L1; TIL-based patient stratification; tertiary lymphoid structures; and TIL evaluation through digital pathology and artificial intelligence are identified as key areas of interest.ConclusionsThis analysis highlights the increasing academic focus on tumor-infiltrating lymphocyte research and identifies key recent themes in the field such as prognostic value of TILs, personalized treatments, and combination therapies.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1511866/fulltumor-infiltrating lymphocytesadoptive cell therapypredictive biomarkerPD-L1bibliometrics |
| spellingShingle | Beibei Wu Beibei Wu Beibei Wu Ding Luo Ding Luo Xuejie Wang Xuejie Wang Chen Qiao Chen Qiao Rui Li Jian Liu Jian Liu The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis Frontiers in Immunology tumor-infiltrating lymphocytes adoptive cell therapy predictive biomarker PD-L1 bibliometrics |
| title | The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis |
| title_full | The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis |
| title_fullStr | The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis |
| title_full_unstemmed | The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis |
| title_short | The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis |
| title_sort | global trends and distribution in tumor infiltrating lymphocytes over the past 49 years bibliometric and visualized analysis |
| topic | tumor-infiltrating lymphocytes adoptive cell therapy predictive biomarker PD-L1 bibliometrics |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1511866/full |
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