Differentiation status determines the effects of IFNγ on the expression of PD-L1 and immunomodulatory genes in melanoma

Differentiation status determines the effects of IFNγ on the expression of PD-L1 and immunomodulatory genes in melanoma

Abstract Background Melanoma cells frequently dedifferentiate in response to inflammation which can increase responses to certain cytokines. Interferon-γ (IFNγ) is an integral part of the anti-tumor immune response and can directly induce both differentiational changes and expression of immunosuppre...

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Main Authors: Teitur Sævarsson, Adrián López García de Lomana, Ólafur Sánchez, Veerle van Esch, Gunnar Bjarni Ragnarsson, Siggeir Fannar Brynjólfsson, Eiríkur Steingrímsson, Berglind Ósk Einarsdóttir
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell Communication and Signaling
Subjects:
Melanoma
Dedifferentiation
Interferon-γ
JAK/STAT pathway
PD-L1
Online Access:https://doi.org/10.1186/s12964-024-01963-6
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