Leptin Levels in Various Manifestations of Pulmonary Tuberculosis
Background. Proinflammatory cytokines are prime candidates as causative agents of the metabolic changes that eventually result in tuberculosis-associated weight loss. Microbial products and cytokines such as TNF and IL-1 increase leptin expression dose dependently in adipose tissue. Leptin plays an...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/64859 |
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| author | Hakan Buyukoglan Inci Gulmez Fahrettin Kelestimur Levent Kart F. Sema Oymak Ramazan Demir Mustafa Ozesmi |
| author_facet | Hakan Buyukoglan Inci Gulmez Fahrettin Kelestimur Levent Kart F. Sema Oymak Ramazan Demir Mustafa Ozesmi |
| author_sort | Hakan Buyukoglan |
| collection | DOAJ |
| description | Background. Proinflammatory cytokines are prime candidates as causative agents of the metabolic changes that eventually result in tuberculosis-associated weight loss. Microbial products and cytokines such as TNF and IL-1 increase leptin expression dose dependently in adipose tissue. Leptin plays an important role in cellular immunity. Objectives. In this study, we investigated serum leptin and TNF-α levels before and after antituberculosis therapy in patients with active pulmonary tuberculosis (TB). Methods. Twenty five in patients with active pulmonary TB and 18 healthy controls participated in the study. Leptin and TNF-α levels were measured before treatment and six months after the treatment and they were compared with the control group. Body mass index (BMI) and chest X-rays before and after the treatment were also evaluated. Results. The leptin levels before and after the treatment were 1.66±1.68 ng/mL and 3.26±3.81 ng/mL, respectively. The leptin levels of tuberculous patients were significant than in healthy
patients (P<.05). The BMI was 19.36±2.55 kg/m2 before the treatment and 22.87±3.13 kg/m2 after the treatment. The TNF-α level was 23.19±12.78 pg/mL before the treatment and 15.95±6.58 pg/mL after the treatment. There was no correlation between leptin and TNF-α levels. Leptin levels were low in patients who had sequela lesion on chest radiographs. Conclusion. Leptin levels are suppressed in tuberculous patients and low leptin levels may contribute to increased susceptibility to infection and recovery with sequela lesions. |
| format | Article |
| id | doaj-art-1d6bffb15c38490d9b0fc20cfe48c2c9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1d6bffb15c38490d9b0fc20cfe48c2c92025-08-20T03:54:37ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/6485964859Leptin Levels in Various Manifestations of Pulmonary TuberculosisHakan Buyukoglan0Inci Gulmez1Fahrettin Kelestimur2Levent Kart3F. Sema Oymak4Ramazan Demir5Mustafa Ozesmi6Department of Pulmonology, Faculty of Medicine, Erciyes University, Kayseri 38200, TurkeyDepartment of Pulmonology, Faculty of Medicine, Erciyes University, Kayseri 38200, TurkeyDepartment of Endocrinology and Metobolism, Faculty of Medicine, Erciyes University, Kayseri 38039, TurkeyDepartment of Pulmonology, Faculty of Medicine, Karaelmas University, Kozlu, Zonguldak 67600, TurkeyDepartment of Pulmonology, Faculty of Medicine, Erciyes University, Kayseri 38200, TurkeyDepartment of Pulmonology, Faculty of Medicine, Erciyes University, Kayseri 38200, TurkeyDepartment of Pulmonology, Faculty of Medicine, Erciyes University, Kayseri 38200, TurkeyBackground. Proinflammatory cytokines are prime candidates as causative agents of the metabolic changes that eventually result in tuberculosis-associated weight loss. Microbial products and cytokines such as TNF and IL-1 increase leptin expression dose dependently in adipose tissue. Leptin plays an important role in cellular immunity. Objectives. In this study, we investigated serum leptin and TNF-α levels before and after antituberculosis therapy in patients with active pulmonary tuberculosis (TB). Methods. Twenty five in patients with active pulmonary TB and 18 healthy controls participated in the study. Leptin and TNF-α levels were measured before treatment and six months after the treatment and they were compared with the control group. Body mass index (BMI) and chest X-rays before and after the treatment were also evaluated. Results. The leptin levels before and after the treatment were 1.66±1.68 ng/mL and 3.26±3.81 ng/mL, respectively. The leptin levels of tuberculous patients were significant than in healthy patients (P<.05). The BMI was 19.36±2.55 kg/m2 before the treatment and 22.87±3.13 kg/m2 after the treatment. The TNF-α level was 23.19±12.78 pg/mL before the treatment and 15.95±6.58 pg/mL after the treatment. There was no correlation between leptin and TNF-α levels. Leptin levels were low in patients who had sequela lesion on chest radiographs. Conclusion. Leptin levels are suppressed in tuberculous patients and low leptin levels may contribute to increased susceptibility to infection and recovery with sequela lesions.http://dx.doi.org/10.1155/2007/64859 |
| spellingShingle | Hakan Buyukoglan Inci Gulmez Fahrettin Kelestimur Levent Kart F. Sema Oymak Ramazan Demir Mustafa Ozesmi Leptin Levels in Various Manifestations of Pulmonary Tuberculosis Mediators of Inflammation |
| title | Leptin Levels in Various Manifestations of Pulmonary Tuberculosis |
| title_full | Leptin Levels in Various Manifestations of Pulmonary Tuberculosis |
| title_fullStr | Leptin Levels in Various Manifestations of Pulmonary Tuberculosis |
| title_full_unstemmed | Leptin Levels in Various Manifestations of Pulmonary Tuberculosis |
| title_short | Leptin Levels in Various Manifestations of Pulmonary Tuberculosis |
| title_sort | leptin levels in various manifestations of pulmonary tuberculosis |
| url | http://dx.doi.org/10.1155/2007/64859 |
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