Cerebellar white and gray matter abnormalities in temporal lobe epilepsy: a voxel-based morphometry study
BackgroundPrevious structural neuroimaging studies linked cerebellar deficits to temporal lobe epilepsy (TLE). The functions of various cerebellar regions are increasingly being valued, and their changes in TLE patients warrant further in-depth investigation. In this study, we used the Spatially Unb...
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Frontiers Media S.A.
2024-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1417342/full |
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| author | Yini Chen Jingyu Pan Andong Lin Lu Sun Yufei Li Hongsen Lin Renwang Pu Ying Wang Yiwei Qi Bo Sun |
| author_facet | Yini Chen Jingyu Pan Andong Lin Lu Sun Yufei Li Hongsen Lin Renwang Pu Ying Wang Yiwei Qi Bo Sun |
| author_sort | Yini Chen |
| collection | DOAJ |
| description | BackgroundPrevious structural neuroimaging studies linked cerebellar deficits to temporal lobe epilepsy (TLE). The functions of various cerebellar regions are increasingly being valued, and their changes in TLE patients warrant further in-depth investigation. In this study, we used the Spatially Unbiased Infratentorial (SUIT) toolbox with a new template to evaluate the cerebellar structural abnormalities in patients with TLE, and further explored the relationship between the changes of different cerebellar regions and cognition.MethodsThirty-two patients with TLE were compared with 39 healthy controls (HC) matched according to age, gender, handedness, and education level. All participants underwent a high-resolution T1-weighted MRI scan on a 3.0 Tesla scanner. We used a voxel-based morphometry (VBM) approach utilizing the SUIT toolbox to provide an optimized and fine-grained exploration of cerebellar structural alterations associated with TLE.ResultsCompared with HC, TLE patients showed a significant reduction in the volume of gray matter in the Left lobule VI and white matter in the Right Crus II. In the TLE patient group, we conducted partial correlation analysis between the volumes of different cerebellar regions and cognitive rating scale scores, such as MMSE and MoCA. The volume of the Left lobule VI (GM) exhibited a positive correlation with the MMSE score, but no significant correlation was found with the MoCA score. Furthermore, it was observed that the MMSE was more effective than the MoCA in identifying epilepsy patients with cognitive impairment.ConclusionThis study supported previous research indicating that temporal lobe epilepsy (TLE) is linked to structural changes in the cerebellum, specifically affecting the volume of gray matter. These findings offer valuable insights into the neurobiology of TLE and hold potential to inform the development of enhanced diagnostic methods and more effective treatment approaches. |
| format | Article |
| id | doaj-art-1d68b945c1fa421a8cc744d8730be33e |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-1d68b945c1fa421a8cc744d8730be33e2025-01-09T13:42:25ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-08-011810.3389/fnins.2024.14173421417342Cerebellar white and gray matter abnormalities in temporal lobe epilepsy: a voxel-based morphometry studyYini Chen0Jingyu Pan1Andong Lin2Lu Sun3Yufei Li4Hongsen Lin5Renwang Pu6Ying Wang7Yiwei Qi8Bo Sun9Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Neurology, The First Affiliated Hospital, Dalian Medical University, Dalian, ChinaDepartment of Neurology, Taizhou Municipal Hospital, Taizhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Dalian Medical University, Dalian, ChinaDepartment of Neurology, The First Affiliated Hospital, Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Neurology, The First Affiliated Hospital, Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaBackgroundPrevious structural neuroimaging studies linked cerebellar deficits to temporal lobe epilepsy (TLE). The functions of various cerebellar regions are increasingly being valued, and their changes in TLE patients warrant further in-depth investigation. In this study, we used the Spatially Unbiased Infratentorial (SUIT) toolbox with a new template to evaluate the cerebellar structural abnormalities in patients with TLE, and further explored the relationship between the changes of different cerebellar regions and cognition.MethodsThirty-two patients with TLE were compared with 39 healthy controls (HC) matched according to age, gender, handedness, and education level. All participants underwent a high-resolution T1-weighted MRI scan on a 3.0 Tesla scanner. We used a voxel-based morphometry (VBM) approach utilizing the SUIT toolbox to provide an optimized and fine-grained exploration of cerebellar structural alterations associated with TLE.ResultsCompared with HC, TLE patients showed a significant reduction in the volume of gray matter in the Left lobule VI and white matter in the Right Crus II. In the TLE patient group, we conducted partial correlation analysis between the volumes of different cerebellar regions and cognitive rating scale scores, such as MMSE and MoCA. The volume of the Left lobule VI (GM) exhibited a positive correlation with the MMSE score, but no significant correlation was found with the MoCA score. Furthermore, it was observed that the MMSE was more effective than the MoCA in identifying epilepsy patients with cognitive impairment.ConclusionThis study supported previous research indicating that temporal lobe epilepsy (TLE) is linked to structural changes in the cerebellum, specifically affecting the volume of gray matter. These findings offer valuable insights into the neurobiology of TLE and hold potential to inform the development of enhanced diagnostic methods and more effective treatment approaches.https://www.frontiersin.org/articles/10.3389/fnins.2024.1417342/fulltemporal lobe epilepsyVBMcerebellumcognitiveMMSE |
| spellingShingle | Yini Chen Jingyu Pan Andong Lin Lu Sun Yufei Li Hongsen Lin Renwang Pu Ying Wang Yiwei Qi Bo Sun Cerebellar white and gray matter abnormalities in temporal lobe epilepsy: a voxel-based morphometry study Frontiers in Neuroscience temporal lobe epilepsy VBM cerebellum cognitive MMSE |
| title | Cerebellar white and gray matter abnormalities in temporal lobe epilepsy: a voxel-based morphometry study |
| title_full | Cerebellar white and gray matter abnormalities in temporal lobe epilepsy: a voxel-based morphometry study |
| title_fullStr | Cerebellar white and gray matter abnormalities in temporal lobe epilepsy: a voxel-based morphometry study |
| title_full_unstemmed | Cerebellar white and gray matter abnormalities in temporal lobe epilepsy: a voxel-based morphometry study |
| title_short | Cerebellar white and gray matter abnormalities in temporal lobe epilepsy: a voxel-based morphometry study |
| title_sort | cerebellar white and gray matter abnormalities in temporal lobe epilepsy a voxel based morphometry study |
| topic | temporal lobe epilepsy VBM cerebellum cognitive MMSE |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1417342/full |
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