Completely conserved VP2 residue K140 of KREMEN1-dependent enteroviruses is critical for virus-receptor interactions and viral infection

Completely conserved VP2 residue K140 of KREMEN1-dependent enteroviruses is critical for virus-receptor interactions and viral infection

ABSTRACT The KREMEN1 (KRM1) protein is a cellular receptor for multiple enteroviruses that cause hand, foot, and mouth disease (HFMD), including coxsackievirus CVA2, CVA3, CVA4, CVA5, CVA6, CVA10, and CVA12. The molecular basis for the broad recognition of these viruses by the KRM1 receptor remains...

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Bibliographic Details
Main Authors: Zeyu Liu, Xue Li, Xiaohong Li, Xingyu Yan, Yuan Tian, Yue Zhao, Kexin Liu, Pei Hao, Shuye Zhang, Chao Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mBio
Subjects:
hand, foot, and mouth disease
enterovirus
KREMEN1 receptor
conservation
Online Access:https://journals.asm.org/doi/10.1128/mbio.03040-24
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