The Pivotal Role of Interleukin-17 in the Pathogenesis of Systemic Lupus Erythematosus
Background: Systemic lupus erythematosus(SLE) is a typical autoimmune illness distinguished by developing many autoantibodies against various cellular components. Interleukin17 (IL-17) is a powerful proinflammatory cytokine that plays an important role in host immunological defense, tissue healing,...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine, University of Kufa
2025-06-01
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| Series: | مجلة الكوفة الطبية |
| Subjects: | |
| Online Access: | https://journal.uokufa.edu.iq/index.php/kmj/article/view/19080 |
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| Summary: | Background: Systemic lupus erythematosus(SLE) is a typical autoimmune illness distinguished by developing many autoantibodies against various cellular components. Interleukin17 (IL-17) is a powerful proinflammatory cytokine that plays an important role in host immunological defense, tissue healing, and the etiology of inflammatory diseases. Purpose: This study aimed to characterize the demographic and clinical profiles of SLE patients and compare IL-17 levels between SLE patients and healthy controls. Methods: 126 participants were enrolled, including SLE patients with ages ranging from 10 to 60 years admitted from Merjan Teaching Hospital and AL-Qassim General Hospital during the period from 1st August 2024 to 31th January 2025. and matched healthy controls. Demographic data and IL-17 levels were collected and analyzed using appropriate non-parametric statistical tests to identify significant differences between groups. The concentrations of IL-17 were assessed using a sandwich (ELISA) assay and a standard curve. Results: Consistent with previous reports, the majority of SLE patients were female (96.8%) and primarily in the 21–40-year age range. While the sex distribution was similar between SLE cases and controls, a significant difference in age distribution was observed (p = 0.027). IL-17 levels (90.30) pg/ml are significantly higher in SLE patients compared to controls (36.70 pg/ml) (p < 0.001), suggesting a foundation for future therapeutic strategies targeting this cytokine. Implications: Further investigations should explore the synergistic effects of IL-17 with other inflammatory cytokines, particularly in lupus nephritis and neuropsychiatric SLE Since the study suggests that IL-17 expression correlates with organ involvement, targeted therapies could be tailored to patients exhibiting IL-17-driven inflammation. Additional materials: the research was approved by the local Department of the Ministry of Health, Babylon Health Directorate committee:1542. Conclusion: Research demonstrates a strong association between IL-17 and lupus nephritis and its contribution to neuropsychiatric manifestations of SLE. IL-17 is a possible biomarker for disease severity, emphasizing its involvement in chronic inflammation mediated by T-helper 17 (Th17) cells. By elucidating the inflammatory pathways driven by IL-17, this study advances the body of scientific knowledge on SLE pathophysiology and provides a foundation for future therapeutic strategies targeting this cytokine
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| ISSN: | 1993-517X 2709-4464 |