Lactobacillus rhamnosus: An emerging probiotic with therapeutic potential for depression
Depression, a complex psychological disorder, involves multiple biological pathways in its pathogenesis. In recent years, the gut-brain axis theory has provided novel insights into the pathogenesis of depression, particularly the crucial role of the gut microbiota in mood regulation. While there rem...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661824004869 |
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| author | Jing Feng Qiuyu Cen Yanru Cui Xiaomin Hu Min Li Linjie Wang Juanfang Wei Nianyi Sun Junyu Wang Anren Zhang |
| author_facet | Jing Feng Qiuyu Cen Yanru Cui Xiaomin Hu Min Li Linjie Wang Juanfang Wei Nianyi Sun Junyu Wang Anren Zhang |
| author_sort | Jing Feng |
| collection | DOAJ |
| description | Depression, a complex psychological disorder, involves multiple biological pathways in its pathogenesis. In recent years, the gut-brain axis theory has provided novel insights into the pathogenesis of depression, particularly the crucial role of the gut microbiota in mood regulation. While there remains no universal consensus on the most efficacious strains for depression treatment, Lactobacillus rhamnosus has risen to prominence within the realm of probiotics for its potential to positively modulate depressive symptoms. This review preliminarily explores the clinical significance of Lactobacillus rhamnosus in the treatment of depression and summarizes the potential mechanisms by which Lactobacillus rhamnosus treats depression, including its regulation of gut microbiota, alterations in gene expression, improvement of intestinal barrier function, maintenance of neurotransmitter balance, suppression of inflammatory responses, modulation of the immune system, coping with oxidative stress, and optimization of metabolic processes. Future research needs to further explore these mechanisms and combine them with clinical research results to optimize treatment plans and provide more effective treatment options for patients with depression. |
| format | Article |
| id | doaj-art-1d58b3e0779e484581de5a9ba2f0f6b7 |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-1d58b3e0779e484581de5a9ba2f0f6b72025-01-09T06:13:02ZengElsevierPharmacological Research1096-11862025-01-01211107541Lactobacillus rhamnosus: An emerging probiotic with therapeutic potential for depressionJing Feng0Qiuyu Cen1Yanru Cui2Xiaomin Hu3Min Li4Linjie Wang5Juanfang Wei6Nianyi Sun7Junyu Wang8Anren Zhang9Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, General Hospital of Western Theater Command, Chengdu, ChinaDepartment of Rehabilitation Medicine, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, General Hospital of Western Theater Command, Chengdu, ChinaCollege of Physical Education and Health, Geely University of China, Chengdu, ChinaDepartment of Rehabilitation Medicine, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, China; Corresponding authors.Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, China; Corresponding authors.Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, China; Corresponding authors.Depression, a complex psychological disorder, involves multiple biological pathways in its pathogenesis. In recent years, the gut-brain axis theory has provided novel insights into the pathogenesis of depression, particularly the crucial role of the gut microbiota in mood regulation. While there remains no universal consensus on the most efficacious strains for depression treatment, Lactobacillus rhamnosus has risen to prominence within the realm of probiotics for its potential to positively modulate depressive symptoms. This review preliminarily explores the clinical significance of Lactobacillus rhamnosus in the treatment of depression and summarizes the potential mechanisms by which Lactobacillus rhamnosus treats depression, including its regulation of gut microbiota, alterations in gene expression, improvement of intestinal barrier function, maintenance of neurotransmitter balance, suppression of inflammatory responses, modulation of the immune system, coping with oxidative stress, and optimization of metabolic processes. Future research needs to further explore these mechanisms and combine them with clinical research results to optimize treatment plans and provide more effective treatment options for patients with depression.http://www.sciencedirect.com/science/article/pii/S1043661824004869Lactobacillus rhamnosusDepressionGut-Brain Axis |
| spellingShingle | Jing Feng Qiuyu Cen Yanru Cui Xiaomin Hu Min Li Linjie Wang Juanfang Wei Nianyi Sun Junyu Wang Anren Zhang Lactobacillus rhamnosus: An emerging probiotic with therapeutic potential for depression Pharmacological Research Lactobacillus rhamnosus Depression Gut-Brain Axis |
| title | Lactobacillus rhamnosus: An emerging probiotic with therapeutic potential for depression |
| title_full | Lactobacillus rhamnosus: An emerging probiotic with therapeutic potential for depression |
| title_fullStr | Lactobacillus rhamnosus: An emerging probiotic with therapeutic potential for depression |
| title_full_unstemmed | Lactobacillus rhamnosus: An emerging probiotic with therapeutic potential for depression |
| title_short | Lactobacillus rhamnosus: An emerging probiotic with therapeutic potential for depression |
| title_sort | lactobacillus rhamnosus an emerging probiotic with therapeutic potential for depression |
| topic | Lactobacillus rhamnosus Depression Gut-Brain Axis |
| url | http://www.sciencedirect.com/science/article/pii/S1043661824004869 |
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