COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study
Purpose The Mother and Child COVID-19 study is a cohort recruiting pregnant women and their children in Cantabria, North of Spain, during COVID-19 pandemic in order to ascertain consequences of SARS-CoV-2 infection on pregnant women and their descendants. This article reports the cohort profile and...
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BMJ Publishing Group
2021-02-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/2/e044224.full |
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| author | Jessica Alonso-Molero Javier Llorca Carolina Lechosa-Muñiz Pilar Gortazar María Fernández-Ortiz Yolanda Jubete Maria J Cabero Bárbara Arozamena Laura Conde-Gil Elsa Cornejo del Río Rocío Cuesta-González Trinidad Dierssen-Sotos Pelayo Frank de Zulueta Inés Gómez-Acebo Coral Llano-Ruiz Lorena Lasarte-Oria Sonia López-Gómez Sonia Mateo-Sota Victoria Orallo Rosa Pardo Daniel Pérez González María Sáez de Adana Herrero |
| author_facet | Jessica Alonso-Molero Javier Llorca Carolina Lechosa-Muñiz Pilar Gortazar María Fernández-Ortiz Yolanda Jubete Maria J Cabero Bárbara Arozamena Laura Conde-Gil Elsa Cornejo del Río Rocío Cuesta-González Trinidad Dierssen-Sotos Pelayo Frank de Zulueta Inés Gómez-Acebo Coral Llano-Ruiz Lorena Lasarte-Oria Sonia López-Gómez Sonia Mateo-Sota Victoria Orallo Rosa Pardo Daniel Pérez González María Sáez de Adana Herrero |
| collection | DOAJ |
| description | Purpose The Mother and Child COVID-19 study is a cohort recruiting pregnant women and their children in Cantabria, North of Spain, during COVID-19 pandemic in order to ascertain consequences of SARS-CoV-2 infection on pregnant women and their descendants. This article reports the cohort profile and preliminary results as recruitment is still open.Participants Three subcohorts can be identified at recruitment. Subcohort 1 includes women giving birth between 23 March and 25 May 2020; they have been retrospectively recruited and could have been exposed to COVID-19 only in their third trimester of pregnancy. Subcohort 2 includes women giving birth from 26 May 2020 on; they are being prospectively recruited and could have been exposed to COVID-19 in both their second and third trimesters of pregnancy. Subcohort 3 includes women in their 12 week of pregnancy prospectively recruited from 26 May 2020 on; they could have been exposed to COVID-19 anytime in their pregnancy. All women are being tested for SARS-CoV-2 infection using both RT-PCR for RNA detection and ELISA for anti-SARS-CoV-2 antibodies. All neonates are being tested for antibodies using immunochemoluminiscency tests; if the mother is tested positive for SARS-CoV-2 RNA, a nasopharyngeal swab is also obtained from the child for RT-PCR analysis.Findings to date As of 22 October, 1167 women have been recruited (266, 354 and 547 for subcohorts 1, 2 and 3, respectively). Fourteen women tested positive to SARS-CoV-2 RNA by the day of delivery. All 14 children born from these women tested negative for SARS-CoV-2 RNA.Future plans Children from women included in subcohort 3 are expected to be recruited by the end of 2020. Children will be followed-up for 1 year in order to ascertain the effect that COVID-19 on their development. |
| format | Article |
| id | doaj-art-1d35f8c2d58b418d9b6f71860b1c0ebf |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-1d35f8c2d58b418d9b6f71860b1c0ebf2024-11-18T19:30:08ZengBMJ Publishing GroupBMJ Open2044-60552021-02-0111210.1136/bmjopen-2020-044224COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study 0Jessica Alonso-MoleroJavier Llorca1Carolina Lechosa-Muñiz2Pilar Gortazar3María Fernández-Ortiz4Yolanda Jubete5Maria J Cabero6Bárbara ArozamenaLaura Conde-GilElsa Cornejo del RíoRocío Cuesta-GonzálezTrinidad Dierssen-SotosPelayo Frank de ZuluetaInés Gómez-AceboCoral Llano-RuizLorena Lasarte-OriaSonia López-GómezSonia Mateo-SotaVictoria OralloRosa Pardo7Daniel Pérez GonzálezMaría Sáez de Adana Herrero4Association of British Neurologists3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, SpainBreastfeeding Coordinator, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, SpainUniversidad de Cantabria Facultad de Medicina, Santander, Cantabria, SpainInstituto de Investigación Sanitaria Valdecilla (IDIVAL), Santander, Cantabria, SpainServicio de Obstetricia y Ginecología, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, SpainUniversidad de Cantabria Facultad de Medicina, Santander, Cantabria, Spain13 Genetics Section, Department of Medicine, Hospital Clinico Universidad de Chile, Santiago, ChilePurpose The Mother and Child COVID-19 study is a cohort recruiting pregnant women and their children in Cantabria, North of Spain, during COVID-19 pandemic in order to ascertain consequences of SARS-CoV-2 infection on pregnant women and their descendants. This article reports the cohort profile and preliminary results as recruitment is still open.Participants Three subcohorts can be identified at recruitment. Subcohort 1 includes women giving birth between 23 March and 25 May 2020; they have been retrospectively recruited and could have been exposed to COVID-19 only in their third trimester of pregnancy. Subcohort 2 includes women giving birth from 26 May 2020 on; they are being prospectively recruited and could have been exposed to COVID-19 in both their second and third trimesters of pregnancy. Subcohort 3 includes women in their 12 week of pregnancy prospectively recruited from 26 May 2020 on; they could have been exposed to COVID-19 anytime in their pregnancy. All women are being tested for SARS-CoV-2 infection using both RT-PCR for RNA detection and ELISA for anti-SARS-CoV-2 antibodies. All neonates are being tested for antibodies using immunochemoluminiscency tests; if the mother is tested positive for SARS-CoV-2 RNA, a nasopharyngeal swab is also obtained from the child for RT-PCR analysis.Findings to date As of 22 October, 1167 women have been recruited (266, 354 and 547 for subcohorts 1, 2 and 3, respectively). Fourteen women tested positive to SARS-CoV-2 RNA by the day of delivery. All 14 children born from these women tested negative for SARS-CoV-2 RNA.Future plans Children from women included in subcohort 3 are expected to be recruited by the end of 2020. Children will be followed-up for 1 year in order to ascertain the effect that COVID-19 on their development.https://bmjopen.bmj.com/content/11/2/e044224.full |
| spellingShingle | Jessica Alonso-Molero Javier Llorca Carolina Lechosa-Muñiz Pilar Gortazar María Fernández-Ortiz Yolanda Jubete Maria J Cabero Bárbara Arozamena Laura Conde-Gil Elsa Cornejo del Río Rocío Cuesta-González Trinidad Dierssen-Sotos Pelayo Frank de Zulueta Inés Gómez-Acebo Coral Llano-Ruiz Lorena Lasarte-Oria Sonia López-Gómez Sonia Mateo-Sota Victoria Orallo Rosa Pardo Daniel Pérez González María Sáez de Adana Herrero COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study BMJ Open |
| title | COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study |
| title_full | COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study |
| title_fullStr | COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study |
| title_full_unstemmed | COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study |
| title_short | COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study |
| title_sort | covid 19 in a cohort of pregnant women and their descendants the moacc 19 study |
| url | https://bmjopen.bmj.com/content/11/2/e044224.full |
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