The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials
Abstract The treatment of infections caused by Staphylococcus hominis remains a challenge, mainly due to the increasing resistance of these bacteria to antibiotics. The aim of the study was to determine antibiotic resistance in 62 strains S. hominis isolated from clinical materials, and to identify...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84500-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559561921626112 |
|---|---|
| author | Magdalena Szemraj Paulina Glajzner Kamila Olszowiec Monika Sienkiewicz |
| author_facet | Magdalena Szemraj Paulina Glajzner Kamila Olszowiec Monika Sienkiewicz |
| author_sort | Magdalena Szemraj |
| collection | DOAJ |
| description | Abstract The treatment of infections caused by Staphylococcus hominis remains a challenge, mainly due to the increasing resistance of these bacteria to antibiotics. The aim of the study was to determine antibiotic resistance in 62 strains S. hominis isolated from clinical materials, and to identify the molecular basis of resistance to antibiotics. Forty-six strains were both methicillin-resistant and harbored the mecA gene. Twenty-three of these strains had mec complex A and ccr complex AB1. Such a combination of the mec and ccr complexes does not correspond to any cassettes that have been demonstrated so far. However, over 80% of the tested strains were multidrug-resistant, of which as many as 12 were resistant to at least seven antibiotics. More than a half of strains harbored the tetK, acc(6’)-Ie aph(2’’), and ant(4’)-I genes. erm(C) was the most common resistant gene to antibiotics from the MLS group. Two strains had as many as five antibiotic resistance genes from the tested groups (erm(C), msr(A), msr(B), mph(C), lnu(A)). The presence of the vga gene encoding resistance to streptogramins A was detected in one strain. All of strains were sensitive to vancomycin. However, 11 of them had reduced sensitivity to this antibiotic and eight of them were characterized by a heterogeneous resistance profile to this antibiotic. Our results clearly shows increasing threat of S. hominis caused by their multi-resistance. Moreover, these bacteria can constitute a reservoir of resistance genes for more pathogenic bacteria. |
| format | Article |
| id | doaj-art-1d352221632c4d3db13ca70dbd285ea7 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-1d352221632c4d3db13ca70dbd285ea72025-01-05T12:23:09ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-024-84500-2The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materialsMagdalena Szemraj0Paulina Glajzner1Kamila Olszowiec2Monika Sienkiewicz3Department of Pharmaceutical Microbiology and Microbiological Diagnostic, Medical University of LodzDepartment of Biopharmacy, Medical University of LodzDepartment of Pharmaceutical Microbiology and Microbiological Diagnostic, Medical University of LodzDepartment of Pharmaceutical Microbiology and Microbiological Diagnostic, Medical University of LodzAbstract The treatment of infections caused by Staphylococcus hominis remains a challenge, mainly due to the increasing resistance of these bacteria to antibiotics. The aim of the study was to determine antibiotic resistance in 62 strains S. hominis isolated from clinical materials, and to identify the molecular basis of resistance to antibiotics. Forty-six strains were both methicillin-resistant and harbored the mecA gene. Twenty-three of these strains had mec complex A and ccr complex AB1. Such a combination of the mec and ccr complexes does not correspond to any cassettes that have been demonstrated so far. However, over 80% of the tested strains were multidrug-resistant, of which as many as 12 were resistant to at least seven antibiotics. More than a half of strains harbored the tetK, acc(6’)-Ie aph(2’’), and ant(4’)-I genes. erm(C) was the most common resistant gene to antibiotics from the MLS group. Two strains had as many as five antibiotic resistance genes from the tested groups (erm(C), msr(A), msr(B), mph(C), lnu(A)). The presence of the vga gene encoding resistance to streptogramins A was detected in one strain. All of strains were sensitive to vancomycin. However, 11 of them had reduced sensitivity to this antibiotic and eight of them were characterized by a heterogeneous resistance profile to this antibiotic. Our results clearly shows increasing threat of S. hominis caused by their multi-resistance. Moreover, these bacteria can constitute a reservoir of resistance genes for more pathogenic bacteria.https://doi.org/10.1038/s41598-024-84500-2Staphylococcus hominisMethicillin resistanceSCCmec cassetteMulti-drug resistance gene |
| spellingShingle | Magdalena Szemraj Paulina Glajzner Kamila Olszowiec Monika Sienkiewicz The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials Scientific Reports Staphylococcus hominis Methicillin resistance SCCmec cassette Multi-drug resistance gene |
| title | The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials |
| title_full | The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials |
| title_fullStr | The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials |
| title_full_unstemmed | The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials |
| title_short | The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials |
| title_sort | prevalence of multidrug resistance in staphylococcus hominis isolated from clinical materials |
| topic | Staphylococcus hominis Methicillin resistance SCCmec cassette Multi-drug resistance gene |
| url | https://doi.org/10.1038/s41598-024-84500-2 |
| work_keys_str_mv | AT magdalenaszemraj theprevalenceofmultidrugresistanceinstaphylococcushominisisolatedfromclinicalmaterials AT paulinaglajzner theprevalenceofmultidrugresistanceinstaphylococcushominisisolatedfromclinicalmaterials AT kamilaolszowiec theprevalenceofmultidrugresistanceinstaphylococcushominisisolatedfromclinicalmaterials AT monikasienkiewicz theprevalenceofmultidrugresistanceinstaphylococcushominisisolatedfromclinicalmaterials AT magdalenaszemraj prevalenceofmultidrugresistanceinstaphylococcushominisisolatedfromclinicalmaterials AT paulinaglajzner prevalenceofmultidrugresistanceinstaphylococcushominisisolatedfromclinicalmaterials AT kamilaolszowiec prevalenceofmultidrugresistanceinstaphylococcushominisisolatedfromclinicalmaterials AT monikasienkiewicz prevalenceofmultidrugresistanceinstaphylococcushominisisolatedfromclinicalmaterials |