Protocol for preparing and using a task to study “delayed safety-seeking behavior” in rats
Summary: The study of defensive behaviors in predicting action outcomes in novel situations without trial and error is limited by the lack of appropriate animal models. Here, we present a protocol for preparing and using a delayed safety-seeking task where rats temporarily hold information for futur...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | STAR Protocols |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666166724005999 |
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| _version_ | 1846162674346360832 |
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| author | Junghwa Lee Sukwoo Choi |
| author_facet | Junghwa Lee Sukwoo Choi |
| author_sort | Junghwa Lee |
| collection | DOAJ |
| description | Summary: The study of defensive behaviors in predicting action outcomes in novel situations without trial and error is limited by the lack of appropriate animal models. Here, we present a protocol for preparing and using a delayed safety-seeking task where rats temporarily hold information for future safety seeking. We describe steps for constructing a two-compartment chamber and provide testing procedures during which either in vivo recordings or optogenetics can be performed. This protocol is applicable for further research on defensive behavior.For complete details on the use and execution of this protocol, please refer to Han et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics. |
| format | Article |
| id | doaj-art-1d3237dbc35b4fb8aea615a95321850c |
| institution | Kabale University |
| issn | 2666-1667 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | STAR Protocols |
| spelling | doaj-art-1d3237dbc35b4fb8aea615a95321850c2024-11-20T05:08:12ZengElsevierSTAR Protocols2666-16672024-12-0154103434Protocol for preparing and using a task to study “delayed safety-seeking behavior” in ratsJunghwa Lee0Sukwoo Choi1School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea; Corresponding authorSchool of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea; Corresponding authorSummary: The study of defensive behaviors in predicting action outcomes in novel situations without trial and error is limited by the lack of appropriate animal models. Here, we present a protocol for preparing and using a delayed safety-seeking task where rats temporarily hold information for future safety seeking. We describe steps for constructing a two-compartment chamber and provide testing procedures during which either in vivo recordings or optogenetics can be performed. This protocol is applicable for further research on defensive behavior.For complete details on the use and execution of this protocol, please refer to Han et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.http://www.sciencedirect.com/science/article/pii/S2666166724005999model organismsneurosciencebehavior |
| spellingShingle | Junghwa Lee Sukwoo Choi Protocol for preparing and using a task to study “delayed safety-seeking behavior” in rats STAR Protocols model organisms neuroscience behavior |
| title | Protocol for preparing and using a task to study “delayed safety-seeking behavior” in rats |
| title_full | Protocol for preparing and using a task to study “delayed safety-seeking behavior” in rats |
| title_fullStr | Protocol for preparing and using a task to study “delayed safety-seeking behavior” in rats |
| title_full_unstemmed | Protocol for preparing and using a task to study “delayed safety-seeking behavior” in rats |
| title_short | Protocol for preparing and using a task to study “delayed safety-seeking behavior” in rats |
| title_sort | protocol for preparing and using a task to study delayed safety seeking behavior in rats |
| topic | model organisms neuroscience behavior |
| url | http://www.sciencedirect.com/science/article/pii/S2666166724005999 |
| work_keys_str_mv | AT junghwalee protocolforpreparingandusingatasktostudydelayedsafetyseekingbehaviorinrats AT sukwoochoi protocolforpreparingandusingatasktostudydelayedsafetyseekingbehaviorinrats |