Salivary Lactate Dehydrogenase Level: A Prognostic Biomarker for Oral Potentially Malignant Disorders
Aim: The study aims to evaluate salivary lactate dehydrogenase (LDH) levels in tobacco users (smoking and/or smokeless) with or without oral potentially malignant diseases (OPMDs), considering into factors like type of habit, duration, and frequency of use. Materials and Methods: The study included...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-11-01
|
| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijdr.ijdr_631_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553198210351104 |
|---|---|
| author | Jigna Shah Kinjal Joshi |
| author_facet | Jigna Shah Kinjal Joshi |
| author_sort | Jigna Shah |
| collection | DOAJ |
| description | Aim:
The study aims to evaluate salivary lactate dehydrogenase (LDH) levels in tobacco users (smoking and/or smokeless) with or without oral potentially malignant diseases (OPMDs), considering into factors like type of habit, duration, and frequency of use.
Materials and Methods:
The study included 60 patients in all, including those who used smokeless tobacco, smoked tobacco, and mixed tobacco and the control group. 1 mL of entire unstimulated saliva was collected using the spit technique and analysed using a semi-autoanalyzer to determine the mean salivary LDH levels.
Result:
The mean salivary LDH level in the control group was lower (128.31) than in the study group. A highly significant (P = 0.000) relationship was discovered between the groups and salivary LDH levels. There was no significant relationship (P > 0.005) between type of habit and mean salivary LDH level. A very significant result was found between the duration of habit in the smoking group (P = 0.000) and the frequency of habit in the smokeless group (P = 0.005).
Conclusion:
Saliva is a biochemical tool that may be easily used in diagnostic methods for mass screening. Mean salivary LDH levels are important for informing patients and increasing awareness about the shift from normal to OPMDs. |
| format | Article |
| id | doaj-art-1d2b515b09ca429a9ece51d191f9f4ff |
| institution | Kabale University |
| issn | 0970-9290 1998-3603 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj-art-1d2b515b09ca429a9ece51d191f9f4ff2025-01-09T11:26:58ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032024-11-0135328528910.4103/ijdr.ijdr_631_23Salivary Lactate Dehydrogenase Level: A Prognostic Biomarker for Oral Potentially Malignant DisordersJigna ShahKinjal JoshiAim: The study aims to evaluate salivary lactate dehydrogenase (LDH) levels in tobacco users (smoking and/or smokeless) with or without oral potentially malignant diseases (OPMDs), considering into factors like type of habit, duration, and frequency of use. Materials and Methods: The study included 60 patients in all, including those who used smokeless tobacco, smoked tobacco, and mixed tobacco and the control group. 1 mL of entire unstimulated saliva was collected using the spit technique and analysed using a semi-autoanalyzer to determine the mean salivary LDH levels. Result: The mean salivary LDH level in the control group was lower (128.31) than in the study group. A highly significant (P = 0.000) relationship was discovered between the groups and salivary LDH levels. There was no significant relationship (P > 0.005) between type of habit and mean salivary LDH level. A very significant result was found between the duration of habit in the smoking group (P = 0.000) and the frequency of habit in the smokeless group (P = 0.005). Conclusion: Saliva is a biochemical tool that may be easily used in diagnostic methods for mass screening. Mean salivary LDH levels are important for informing patients and increasing awareness about the shift from normal to OPMDs.https://journals.lww.com/10.4103/ijdr.ijdr_631_23oral potentially malignant disorderssalivary ldh levelsmokeless and/or smoking tobacco |
| spellingShingle | Jigna Shah Kinjal Joshi Salivary Lactate Dehydrogenase Level: A Prognostic Biomarker for Oral Potentially Malignant Disorders Indian Journal of Dental Research oral potentially malignant disorders salivary ldh level smokeless and/or smoking tobacco |
| title | Salivary Lactate Dehydrogenase Level: A Prognostic Biomarker for Oral Potentially Malignant Disorders |
| title_full | Salivary Lactate Dehydrogenase Level: A Prognostic Biomarker for Oral Potentially Malignant Disorders |
| title_fullStr | Salivary Lactate Dehydrogenase Level: A Prognostic Biomarker for Oral Potentially Malignant Disorders |
| title_full_unstemmed | Salivary Lactate Dehydrogenase Level: A Prognostic Biomarker for Oral Potentially Malignant Disorders |
| title_short | Salivary Lactate Dehydrogenase Level: A Prognostic Biomarker for Oral Potentially Malignant Disorders |
| title_sort | salivary lactate dehydrogenase level a prognostic biomarker for oral potentially malignant disorders |
| topic | oral potentially malignant disorders salivary ldh level smokeless and/or smoking tobacco |
| url | https://journals.lww.com/10.4103/ijdr.ijdr_631_23 |
| work_keys_str_mv | AT jignashah salivarylactatedehydrogenaselevelaprognosticbiomarkerfororalpotentiallymalignantdisorders AT kinjaljoshi salivarylactatedehydrogenaselevelaprognosticbiomarkerfororalpotentiallymalignantdisorders |