Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort

Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort

Altered cholesterol metabolism is implicated in brain ageing and Alzheimer’s disease. We examined whether key genes regulating cholesterol metabolism and levels of brain cholesterol are altered in dementia and Alzheimer’s disease neuropathological change (ADNC). Temporal cortex (n = 99) was obtained...

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Bibliographic Details
Main Authors: Hemant Mistry, Connor D. Richardson, Adrian Higginbottom, Bridget Ashford, Saif U. Ahamed, Zoe Moore, Fiona E. Matthews, Carol Brayne, Julie E. Simpson, Stephen B. Wharton
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Neuroscience Research
Subjects:
Cholesterol
HMG-CoA reductase
Sterol regulatory element-binding proteins
Dementia
Alzheimer’s disease
Cognitive Function and Ageing Study
Online Access:http://www.sciencedirect.com/science/article/pii/S0168010224000075
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