SLAMF7 (CD319) enhances cytotoxic T-cell differentiation and sensitizes CD8+ T cells to immune checkpoint blockade

SLAMF7 (CD319) enhances cytotoxic T-cell differentiation and sensitizes CD8+ T cells to immune checkpoint blockade

Tumors frequently evade immune destruction by impairing cytotoxic CD8+ T-cell responses, highlighting the need for strategies that restore T-cell functionality. Here, we identify SLAMF7 (CD319) as a key enhancer of human CD8+ T-cell responses against tumors. SLAMF7 expression is induced by pro-infla...

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Bibliographic Details
Main Authors: Jan-Erik Sander, Irina Han, Lisette Fickenscher, Jörg-Peter Schmidt, Hartmut Kroll, Tereza Vosikova, Martin Durisin, Holger Lingel, Monika C. Brunner-Weinzierl
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
SLAMF family
T-cell differentiation
cytotoxicity
costimulation
cancer
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1654374/full
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