Preoperative mapping techniques for brain tumor surgery: a systematic review
Accurate preoperative mapping is crucial for maximizing tumor removal while minimizing damage to critical brain functions during brain tumor surgery. Navigated transcranial magnetic stimulation (nTMS), magnetoencephalography (MEG), and functional magnetic resonance imaging (fMRI) are established met...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1481430/full |
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| author | Augusto Leone Augusto Leone Francesco Carbone Francesco Carbone Uwe Spetzger Peter Vajkoczy Giovanni Raffa Flavio Angileri Antonino Germanó Melina Engelhardt Thomas Picht Thomas Picht Antonio Colamaria Tizian Rosenstock Tizian Rosenstock |
| author_facet | Augusto Leone Augusto Leone Francesco Carbone Francesco Carbone Uwe Spetzger Peter Vajkoczy Giovanni Raffa Flavio Angileri Antonino Germanó Melina Engelhardt Thomas Picht Thomas Picht Antonio Colamaria Tizian Rosenstock Tizian Rosenstock |
| author_sort | Augusto Leone |
| collection | DOAJ |
| description | Accurate preoperative mapping is crucial for maximizing tumor removal while minimizing damage to critical brain functions during brain tumor surgery. Navigated transcranial magnetic stimulation (nTMS), magnetoencephalography (MEG), and functional magnetic resonance imaging (fMRI) are established methods for assessing motor and language function. Following PRISMA guidelines, this systematic review analyzes the reliability, clinical utility, and accessibility of these techniques. A total of 128 studies (48 nTMS, 56 fMRI, 24 MEG) were identified from various databases. The analysis finds nTMS to be a safe, standardized method with high accuracy compared to direct cortical stimulation for preoperative motor mapping. Combining nTMS with tractography allows for preoperative assessment of short-term and long-term motor deficits, which may not be possible with fMRI. fMRI data interpretation requires careful consideration of co-activated, non-essential areas (potentially leading to false positives) and situations where neural activity and blood flow are uncoupled (potentially leading to false negatives). These limitations restrict fMRI’s role in preoperative planning for both motor and language functions. While MEG offers high accuracy in motor mapping, its high cost and technical complexity contribute to the limited number of available studies. Studies comparing preoperative language mapping techniques with direct cortical stimulation show significant variability across all methods, highlighting the need for larger, multicenter studies for validation. Repetitive nTMS speech mapping offers valuable negative predictive value, allowing clinicians to evaluate whether a patient should undergo awake or asleep surgery. Language function monitoring heavily relies on the specific expertise and experience available at each center, making it challenging to establish general recommendations. |
| format | Article |
| id | doaj-art-1d133d00c5ae45c1b8e652364d75451e |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-1d133d00c5ae45c1b8e652364d75451e2025-01-07T06:41:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14814301481430Preoperative mapping techniques for brain tumor surgery: a systematic reviewAugusto Leone0Augusto Leone1Francesco Carbone2Francesco Carbone3Uwe Spetzger4Peter Vajkoczy5Giovanni Raffa6Flavio Angileri7Antonino Germanó8Melina Engelhardt9Thomas Picht10Thomas Picht11Antonio Colamaria12Tizian Rosenstock13Tizian Rosenstock14Department of Neurosurgery, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GermanyDepartment of Neurosurgery, Städtisches Klinikum Karlsruhe, Karlsruhe, GermanyDepartment of Neurosurgery, Städtisches Klinikum Karlsruhe, Karlsruhe, GermanyDepartment of Neurosurgery, University of Foggia, Foggia, ItalyDepartment of Neurosurgery, Städtisches Klinikum Karlsruhe, Karlsruhe, GermanyDepartment of Neurosurgery, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GermanyDepartment of Neurosurgery, University of Messina, Messina, ItalyDepartment of Neurosurgery, University of Messina, Messina, ItalyDepartment of Neurosurgery, University of Messina, Messina, ItalyDepartment of Neurosurgery, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GermanyDepartment of Neurosurgery, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GermanyCluster of Excellence: “Matters of Activity. Image Space Material,” Humboldt University, Berlin, GermanyDepartment of Neurosurgery, University of Foggia, Foggia, ItalyDepartment of Neurosurgery, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GermanyBerlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin Institute of Health (BIH) Biomedical Innovation Academy, BIH Charité Digital Clinician Scientist Program, Berlin, GermanyAccurate preoperative mapping is crucial for maximizing tumor removal while minimizing damage to critical brain functions during brain tumor surgery. Navigated transcranial magnetic stimulation (nTMS), magnetoencephalography (MEG), and functional magnetic resonance imaging (fMRI) are established methods for assessing motor and language function. Following PRISMA guidelines, this systematic review analyzes the reliability, clinical utility, and accessibility of these techniques. A total of 128 studies (48 nTMS, 56 fMRI, 24 MEG) were identified from various databases. The analysis finds nTMS to be a safe, standardized method with high accuracy compared to direct cortical stimulation for preoperative motor mapping. Combining nTMS with tractography allows for preoperative assessment of short-term and long-term motor deficits, which may not be possible with fMRI. fMRI data interpretation requires careful consideration of co-activated, non-essential areas (potentially leading to false positives) and situations where neural activity and blood flow are uncoupled (potentially leading to false negatives). These limitations restrict fMRI’s role in preoperative planning for both motor and language functions. While MEG offers high accuracy in motor mapping, its high cost and technical complexity contribute to the limited number of available studies. Studies comparing preoperative language mapping techniques with direct cortical stimulation show significant variability across all methods, highlighting the need for larger, multicenter studies for validation. Repetitive nTMS speech mapping offers valuable negative predictive value, allowing clinicians to evaluate whether a patient should undergo awake or asleep surgery. Language function monitoring heavily relies on the specific expertise and experience available at each center, making it challenging to establish general recommendations.https://www.frontiersin.org/articles/10.3389/fonc.2024.1481430/fullnavigated transcranial magnetic stimulation (nTMS)magnetoencephalography (MEG)fMRIbrain mappingpreoperative mappingbrain tumor surgery |
| spellingShingle | Augusto Leone Augusto Leone Francesco Carbone Francesco Carbone Uwe Spetzger Peter Vajkoczy Giovanni Raffa Flavio Angileri Antonino Germanó Melina Engelhardt Thomas Picht Thomas Picht Antonio Colamaria Tizian Rosenstock Tizian Rosenstock Preoperative mapping techniques for brain tumor surgery: a systematic review Frontiers in Oncology navigated transcranial magnetic stimulation (nTMS) magnetoencephalography (MEG) fMRI brain mapping preoperative mapping brain tumor surgery |
| title | Preoperative mapping techniques for brain tumor surgery: a systematic review |
| title_full | Preoperative mapping techniques for brain tumor surgery: a systematic review |
| title_fullStr | Preoperative mapping techniques for brain tumor surgery: a systematic review |
| title_full_unstemmed | Preoperative mapping techniques for brain tumor surgery: a systematic review |
| title_short | Preoperative mapping techniques for brain tumor surgery: a systematic review |
| title_sort | preoperative mapping techniques for brain tumor surgery a systematic review |
| topic | navigated transcranial magnetic stimulation (nTMS) magnetoencephalography (MEG) fMRI brain mapping preoperative mapping brain tumor surgery |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1481430/full |
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