Early life stress and hormonal status influence orexin‐1 receptor expression in structures regulating cardiorespiratory responses to CO2

Early life stress and hormonal status influence orexin‐1 receptor expression in structures regulating cardiorespiratory responses to CO2

Abstract Excessive cardiorespiratory responses to CO2 are a hallmark of panic disorder (PD). Female sex and exposure to early life stress are risk factors for PD. Neonatal maternal separation (NMS; 3 h/day, postnatal days 3–12) augments the ventilatory response to CO2 by ∼35% relative to controls; t...

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Bibliographic Details
Main Authors: Stéphanie Fournier, Julie Plamondon, Denis Richard, Richard Kinkead
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Experimental Physiology
Subjects:
CO2 response
control of breathing
orexin
sex based‐differences
stress
Online Access:https://doi.org/10.1113/EP092431
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