Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32

Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32

Abstract The enzyme complex KEOPS (Kinase, Endopeptidase and Other Proteins of Small size) installs the universally conserved and essential N6-threonylcarbamoyl adenosine modification (t6A) on ANN-decoding tRNAs in eukaryotes and in archaea. KEOPS consists of Cgi121, Kae1, Pcc1, Gon7 and the atypica...

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Main Authors: Samara Mishelle Ona Chuquimarca, Jonah Beenstock, Salima Daou, Jennifer Porat, Alexander F. A. Keszei, Jay Z. Yin, Tobias Beschauner, Mark A. Bayfield, Mohammad T. Mazhab-Jafari, Frank Sicheri
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54787-w
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https://doi.org/10.1038/s41467-024-54787-w

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