Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples
Head and neck cancer (HNC) is a diverse group of malignancies arising in the mucosal linings of the oral cavity, pharynx, and larynx, influenced by factors such as tobacco use, alcohol consumption, and human papillomavirus (HPV) infection. This study conducts a comprehensive meta-analysis of the mut...
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| Language: | English |
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Elsevier
2024-09-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024004746 |
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| author | Srikanth S. Manda Nafisa Arfa Neha Sharma Aparna R. Parikh Thomas J. Roberts Sewanti Limaye Venkataraman Ramachandran Kumar Prabhash Moni A. Kuriakose Prashant Kumar |
| author_facet | Srikanth S. Manda Nafisa Arfa Neha Sharma Aparna R. Parikh Thomas J. Roberts Sewanti Limaye Venkataraman Ramachandran Kumar Prabhash Moni A. Kuriakose Prashant Kumar |
| author_sort | Srikanth S. Manda |
| collection | DOAJ |
| description | Head and neck cancer (HNC) is a diverse group of malignancies arising in the mucosal linings of the oral cavity, pharynx, and larynx, influenced by factors such as tobacco use, alcohol consumption, and human papillomavirus (HPV) infection. This study conducts a comprehensive meta-analysis of the mutational landscape of HNC across Asian cohorts, encompassing India, Korea, Japan, China, Singapore, and Saudi Arabia. The analysis highlights distinct genetic profiles influenced by environmental exposures, lifestyle habits, and genetic predispositions. Notably, the RAF family proteins, enriched in both Indian and Chinese cohorts, present potential therapeutic targets for RAF inhibitors like Vemurafenib. Additionaly, specific mutations like MET in Singaporean patients can be effectively addressed with drugs like Crizotinib, leading to rapid responses in HNSCC. Smokers exhibited high frequencies of CASP8 and FAT1 mutations. Novel driver genes, including RYR2 and ANK2, emerged with significant mutational frequencies in smokers. The RAS signaling pathway was identified as a prominent driver in HNC, contrasting with the globally prevalent PIK3CA/MTOR pathway. This study also underscores the high prevalence of HRAS mutations in Indian and Saudi cohorts. The study emphasizes the necessity for region-specific data to understand the unique molecular differences and develop effective therapies. The identification of NBEA and ANK2 as potential novel driver genes in HNC highlights new avenues for research and targeted therapeutic interventions tailored to the genetic profiles of Asian HNC patients. |
| format | Article |
| id | doaj-art-1d05fba69e4b4eebb40d248bad4aa6d3 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-1d05fba69e4b4eebb40d248bad4aa6d32025-01-09T06:16:58ZengElsevierOral Oncology Reports2772-90602024-09-0111100628Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samplesSrikanth S. Manda0Nafisa Arfa1Neha Sharma2Aparna R. Parikh3Thomas J. Roberts4Sewanti Limaye5Venkataraman Ramachandran6Kumar Prabhash7Moni A. Kuriakose8Prashant Kumar9Karkinos Foundation, Mumbai, Maharashtra, 400086, India; Karkinos Healthcare Pvt Ltd, Navi Mumbai, Maharashtra, 400705, IndiaDepartment of Chemical Engineering, Indian Institute of Technology, Guwahati, Assam, 781039, IndiaKarkinos Foundation, Mumbai, Maharashtra, 400086, India; Karkinos Healthcare Pvt Ltd, Navi Mumbai, Maharashtra, 400705, IndiaCancer Center, Massachusetts General Hospital, Boston, MA, 02114, USACancer Center, Massachusetts General Hospital, Boston, MA, 02114, USADepartment of Medical and Precision Oncology, Sir HN Reliance Foundation Hospital and Research Centre, Mumbai, 400004, Maharashtra, IndiaKarkinos Foundation, Mumbai, Maharashtra, 400086, India; Karkinos Healthcare Pvt Ltd, Navi Mumbai, Maharashtra, 400705, IndiaHomi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, 400094, Maharashtra, India; Department of Medical Oncology, Tata Memorial Hospital, Mumbai, 400012, Maharashtra, IndiaKarkinos Foundation, Mumbai, Maharashtra, 400086, India; Karkinos Healthcare Pvt Ltd, Navi Mumbai, Maharashtra, 400705, IndiaKarkinos Foundation, Mumbai, Maharashtra, 400086, India; Karkinos Healthcare Pvt Ltd, Navi Mumbai, Maharashtra, 400705, India; Centre of Excellence for Cancer – Gangwal School of Medical Sciences and Technology, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, 208016, India; Corresponding author. Karkinos Foundation, India.Head and neck cancer (HNC) is a diverse group of malignancies arising in the mucosal linings of the oral cavity, pharynx, and larynx, influenced by factors such as tobacco use, alcohol consumption, and human papillomavirus (HPV) infection. This study conducts a comprehensive meta-analysis of the mutational landscape of HNC across Asian cohorts, encompassing India, Korea, Japan, China, Singapore, and Saudi Arabia. The analysis highlights distinct genetic profiles influenced by environmental exposures, lifestyle habits, and genetic predispositions. Notably, the RAF family proteins, enriched in both Indian and Chinese cohorts, present potential therapeutic targets for RAF inhibitors like Vemurafenib. Additionaly, specific mutations like MET in Singaporean patients can be effectively addressed with drugs like Crizotinib, leading to rapid responses in HNSCC. Smokers exhibited high frequencies of CASP8 and FAT1 mutations. Novel driver genes, including RYR2 and ANK2, emerged with significant mutational frequencies in smokers. The RAS signaling pathway was identified as a prominent driver in HNC, contrasting with the globally prevalent PIK3CA/MTOR pathway. This study also underscores the high prevalence of HRAS mutations in Indian and Saudi cohorts. The study emphasizes the necessity for region-specific data to understand the unique molecular differences and develop effective therapies. The identification of NBEA and ANK2 as potential novel driver genes in HNC highlights new avenues for research and targeted therapeutic interventions tailored to the genetic profiles of Asian HNC patients.http://www.sciencedirect.com/science/article/pii/S2772906024004746Head and neck cancerHNSCCAsiaWESNGSMutations |
| spellingShingle | Srikanth S. Manda Nafisa Arfa Neha Sharma Aparna R. Parikh Thomas J. Roberts Sewanti Limaye Venkataraman Ramachandran Kumar Prabhash Moni A. Kuriakose Prashant Kumar Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples Oral Oncology Reports Head and neck cancer HNSCC Asia WES NGS Mutations |
| title | Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples |
| title_full | Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples |
| title_fullStr | Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples |
| title_full_unstemmed | Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples |
| title_short | Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples |
| title_sort | genomic landscape of head and neck cancer in asia a comprehensive meta analysis of 1016 samples |
| topic | Head and neck cancer HNSCC Asia WES NGS Mutations |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024004746 |
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