Biophysical and biochemical signatures of pancreatic stellate cell activation: insights into mechano-metabolic signalling from atomic force microscopy and Raman spectroscopy

Biophysical and biochemical signatures of pancreatic stellate cell activation: insights into mechano-metabolic signalling from atomic force microscopy and Raman spectroscopy

Abstract Background Pancreatic fibrosis is a key pathological feature of chronic pancreatitis and pancreatic cancer, driven by the persistent activation of pancreatic stellate cells. These cells, normally quiescent, undergo profound phenotypic changes in response to environmental cues, yet the inter...

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Main Authors: Jacek J. Litewka, Monika A. Jakubowska, Marta Targosz-Korecka, Ewelina Wiercigroch, Jakub Dybas, Natalia Cisak, Zbigniew Madeja, Pawel E. Ferdek
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cell Communication and Signaling
Subjects:
Pancreatic stellate cells
Fibrosis
Lipid metabolism
Cytoskeletal remodelling
Mechanical properties
Raman spectroscopy
Online Access:https://doi.org/10.1186/s12964-025-02354-1
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https://doi.org/10.1186/s12964-025-02354-1

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