Combining culture optimization and synthetic biology to improve production and detection of secondary metabolites in Myxococcus xanthus: application to myxoprincomide

Combining culture optimization and synthetic biology to improve production and detection of secondary metabolites in Myxococcus xanthus: application to myxoprincomide

ABSTRACT Microbial secondary metabolites play crucial ecological roles in governing species interactions and contributing to their defense strategies. Their unique structures and potent bioactivities have been key in discovering antibiotics and anticancer drugs. Genome sequencing has undoubtedly rev...

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Bibliographic Details
Main Authors: Mathieu Sourice, Charlotte Simmler, Marc Maresca, Béatrice Py, Corinne Aubert
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:Microbiology Spectrum
Subjects:
myxobacteria
secondary metabolites
biosynthetic gene cluster
natural products
chassis strain
synthetic biology
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01740-24
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