The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24–59 months
Soil-transmitted helminth (STH) among children aged 24–59 months is one cause of chronic infection that could lead to stunting. The association of 25(OH)D and immune responses during chronic infection in stunted populations has not yet been well established. An association study of case–control data...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Autoimmunity |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/08916934.2024.2330394 |
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| author | Riyadi Adrizain Monika Verena Nagari Djatnika Setiabudi Afiat Berbudi Budi Setiabudiawan |
| author_facet | Riyadi Adrizain Monika Verena Nagari Djatnika Setiabudi Afiat Berbudi Budi Setiabudiawan |
| author_sort | Riyadi Adrizain |
| collection | DOAJ |
| description | Soil-transmitted helminth (STH) among children aged 24–59 months is one cause of chronic infection that could lead to stunting. The association of 25(OH)D and immune responses during chronic infection in stunted populations has not yet been well established. An association study of case–control data was conducted in Bandung district from October 2019 to January 2023. Sociodemographic factors, stool samples, and serum levels of 25(OH)D, interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13) were assessed. Statistical analysis was performed to evaluate the prevalence and association of 25(OH)D, IL-4, IL-5, and IL-13 with the burden of STH infection in stunted children. In total, 401 stunted children were recruited. A higher burden of STH infection was found for lower levels of IL-5 (r = −0.477; p = 0.004) and IL-13 (r = −0.433; p = 0.028). Thus, 25(OH)D, IL-4, IL-5, and IL-13 play a role in the burden of STH infection. |
| format | Article |
| id | doaj-art-1c60a1e40b8448d39fdd14c20e2638f2 |
| institution | Kabale University |
| issn | 0891-6934 1607-842X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autoimmunity |
| spelling | doaj-art-1c60a1e40b8448d39fdd14c20e2638f22024-12-04T06:11:51ZengTaylor & Francis GroupAutoimmunity0891-69341607-842X2024-12-0157110.1080/08916934.2024.2330394The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24–59 monthsRiyadi Adrizain0Monika Verena Nagari1Djatnika Setiabudi2Afiat Berbudi3Budi Setiabudiawan4Department of Child Health, Faculty of Medicine, Universitas Padjadjaran Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaFaculty of Medicine, Universitas Padjadjaran, Bandung, IndonesiaDepartment of Child Health, Faculty of Medicine, Universitas Padjadjaran Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaDepartment of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung, IndonesiaDepartment of Child Health, Faculty of Medicine, Universitas Padjadjaran Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaSoil-transmitted helminth (STH) among children aged 24–59 months is one cause of chronic infection that could lead to stunting. The association of 25(OH)D and immune responses during chronic infection in stunted populations has not yet been well established. An association study of case–control data was conducted in Bandung district from October 2019 to January 2023. Sociodemographic factors, stool samples, and serum levels of 25(OH)D, interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13) were assessed. Statistical analysis was performed to evaluate the prevalence and association of 25(OH)D, IL-4, IL-5, and IL-13 with the burden of STH infection in stunted children. In total, 401 stunted children were recruited. A higher burden of STH infection was found for lower levels of IL-5 (r = −0.477; p = 0.004) and IL-13 (r = −0.433; p = 0.028). Thus, 25(OH)D, IL-4, IL-5, and IL-13 play a role in the burden of STH infection.https://www.tandfonline.com/doi/10.1080/08916934.2024.2330394STH infectionstunting25(OH)dIL-4IL-5IL-13 |
| spellingShingle | Riyadi Adrizain Monika Verena Nagari Djatnika Setiabudi Afiat Berbudi Budi Setiabudiawan The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24–59 months Autoimmunity STH infection stunting 25(OH)d IL-4 IL-5 IL-13 |
| title | The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24–59 months |
| title_full | The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24–59 months |
| title_fullStr | The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24–59 months |
| title_full_unstemmed | The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24–59 months |
| title_short | The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24–59 months |
| title_sort | association of 25 oh d interleukin 4 interleukin 5 and interleukin 13 levels with the burden of soil transmitted helminth infection in stunted children aged 24 59 months |
| topic | STH infection stunting 25(OH)d IL-4 IL-5 IL-13 |
| url | https://www.tandfonline.com/doi/10.1080/08916934.2024.2330394 |
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