Harnessing exosomes as a platform for drug delivery in breast cancer: A systematic review for in vivo and in vitro studies
Breast cancer remains a significant global health concern, emphasizing the critical need for effective treatment strategies, especially targeted therapies. This systematic review summarizes the findings from in vitro and in vivo studies regarding the therapeutic potential of exosomes as drug deliver...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Molecular Therapy: Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950329924000420 |
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| author | Abdulwahab Teflischi Gharavi Saeed Irian Azadeh Niknejad Keykavous Parang Mona Salimi |
| author_facet | Abdulwahab Teflischi Gharavi Saeed Irian Azadeh Niknejad Keykavous Parang Mona Salimi |
| author_sort | Abdulwahab Teflischi Gharavi |
| collection | DOAJ |
| description | Breast cancer remains a significant global health concern, emphasizing the critical need for effective treatment strategies, especially targeted therapies. This systematic review summarizes the findings from in vitro and in vivo studies regarding the therapeutic potential of exosomes as drug delivery platforms in the field of breast cancer treatment. A comprehensive search was conducted across bibliographic datasets, including Web of Science, PubMed, and Scopus, using relevant queries from several related published articles and the Medical Subject Headings Database. Then, all morphological, biomechanical, histopathological, and cellular-molecular outcomes were systematically collected. A total of 30 studies were identified based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. These studies underwent assessment using the Systematic Review Centre for Laboratory Animal Experimentation risk of bias assessment tool. The results indicate that exosomes exhibit promise as effective drug delivery platforms, capable of hindering cancer cell viability, proliferation, migration, and angiogenesis. However, a comprehensive assessment is challenging due to some studies deviating from guidelines and having incomplete methodology. Addressing these, future studies should detail methodologies, optimize dosing, and enhance exosome production. Standardization in reporting, consistent protocols, and exploration of alternative sources are crucial. |
| format | Article |
| id | doaj-art-1c55e76675af427d98ff8861747ee66b |
| institution | Kabale University |
| issn | 2950-3299 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncology |
| spelling | doaj-art-1c55e76675af427d98ff8861747ee66b2024-11-24T04:15:34ZengElsevierMolecular Therapy: Oncology2950-32992024-06-01322200800Harnessing exosomes as a platform for drug delivery in breast cancer: A systematic review for in vivo and in vitro studiesAbdulwahab Teflischi Gharavi0Saeed Irian1Azadeh Niknejad2Keykavous Parang3Mona Salimi4Department of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran; Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, IranDepartment of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran, IranDepartment of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran, IranCenter for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA 92618-1908, USA; Corresponding author: Keykavous Parang, PharmD, PhD, Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA 92618-1908, USA.Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran; Corresponding author: Mona Salimi, PhD, Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.Breast cancer remains a significant global health concern, emphasizing the critical need for effective treatment strategies, especially targeted therapies. This systematic review summarizes the findings from in vitro and in vivo studies regarding the therapeutic potential of exosomes as drug delivery platforms in the field of breast cancer treatment. A comprehensive search was conducted across bibliographic datasets, including Web of Science, PubMed, and Scopus, using relevant queries from several related published articles and the Medical Subject Headings Database. Then, all morphological, biomechanical, histopathological, and cellular-molecular outcomes were systematically collected. A total of 30 studies were identified based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. These studies underwent assessment using the Systematic Review Centre for Laboratory Animal Experimentation risk of bias assessment tool. The results indicate that exosomes exhibit promise as effective drug delivery platforms, capable of hindering cancer cell viability, proliferation, migration, and angiogenesis. However, a comprehensive assessment is challenging due to some studies deviating from guidelines and having incomplete methodology. Addressing these, future studies should detail methodologies, optimize dosing, and enhance exosome production. Standardization in reporting, consistent protocols, and exploration of alternative sources are crucial.http://www.sciencedirect.com/science/article/pii/S2950329924000420breast cancerdrug deliveryexosomesmall extracellular vesiclessystematic review |
| spellingShingle | Abdulwahab Teflischi Gharavi Saeed Irian Azadeh Niknejad Keykavous Parang Mona Salimi Harnessing exosomes as a platform for drug delivery in breast cancer: A systematic review for in vivo and in vitro studies Molecular Therapy: Oncology breast cancer drug delivery exosome small extracellular vesicles systematic review |
| title | Harnessing exosomes as a platform for drug delivery in breast cancer: A systematic review for in vivo and in vitro studies |
| title_full | Harnessing exosomes as a platform for drug delivery in breast cancer: A systematic review for in vivo and in vitro studies |
| title_fullStr | Harnessing exosomes as a platform for drug delivery in breast cancer: A systematic review for in vivo and in vitro studies |
| title_full_unstemmed | Harnessing exosomes as a platform for drug delivery in breast cancer: A systematic review for in vivo and in vitro studies |
| title_short | Harnessing exosomes as a platform for drug delivery in breast cancer: A systematic review for in vivo and in vitro studies |
| title_sort | harnessing exosomes as a platform for drug delivery in breast cancer a systematic review for in vivo and in vitro studies |
| topic | breast cancer drug delivery exosome small extracellular vesicles systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S2950329924000420 |
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