Effect of <i>CTLA4</i> gene polymorphism on relapse probability among patients with acute leukemias after allogenic hematopoietic stem cells transplantation

Effect of <i>CTLA4</i> gene polymorphism on relapse probability among patients with acute leukemias after allogenic hematopoietic stem cells transplantation

Background. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is being widely applied as a therapy for hematological malignancies. The long-term outcome of allo-HSCT depends directly on the ability of cytotoxic T-lymphocytes to recognize and eliminate the residual tumor. CTLA-4 is one o...

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Bibliographic Details
Main Authors: D. S. Romaniuk, A. A. Khmelevskaya, M. Yu. Drokov, N. N. Popova, V. A. Vasilieva, L. A. Kuzmina, G. A. Efimov, E. N. Parovichnikova, V. G. Savchenko
Format: Article
Language:Russian
Published: ABV-press 2019-04-01
Series:Онкогематология
Subjects:
allogeneic hematopoietic stem cell transplantation
graft versus host disease
allele-specific polymerase chain reaction
nonsynonymous single nucleotide polymorphism
ctla4
Online Access:https://oncohematology.abvpress.ru/ongm/article/view/337
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