Promotor Hypomethylation Mediated Upregulation of VCAN Targets Twist1 to Promote EndMT in Hypoxia‐Induced Pulmonary Hypertension

Promotor Hypomethylation Mediated Upregulation of VCAN Targets Twist1 to Promote EndMT in Hypoxia‐Induced Pulmonary Hypertension

Background Hypoxia‐induced pulmonary hypertension (HPH) is a severe vascular disorder that is characterized by the involvement of endothelial‐to‐mesenchymal transition (EndMT) in its pathogenesis. Our previous research has suggested that the gene versican may have a crucial role in the development o...

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Bibliographic Details
Main Authors: Jinyan Yu, Shanchao Hong, Lingjia Yang, Shugao Ye, Zhen Yu, Zheming Zhang, Ziteng Wang, Shulun Huang, Yuan Chen, Tao Bian, Yan Wu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
DNA methylation
endothelial‐to‐mesenchymal transition
hypoxia‐induced pulmonary hypertension
Twist1
versican
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.036969
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