Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK [version 1; peer review: 2 approved]
Liver disease is a major, and increasing, cause of death in the UK. The UK Chronic Liver Failure network (UK-CLIF) was developed as a multi-stakeholder network with the aim to advance cirrhosis research, with emphasis on geographical areas of high disease prevalence or limited research activity. The...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2024-11-01
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| Online Access: | https://openresearch.nihr.ac.uk/articles/4-69/v1 |
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| author | Yvanne Enever Oliver Tavabie Juan Acevedo Richard Allen Brian Hogan Abhishek Chauhan Rajeshwar Mookerjee Vishal Patel Richard Aspinall Gavin Wright Andrew Cook Stuart McPherson Gautam Mehta Rajiv Jalan Milton Silverman Helen Crisp |
| author_facet | Yvanne Enever Oliver Tavabie Juan Acevedo Richard Allen Brian Hogan Abhishek Chauhan Rajeshwar Mookerjee Vishal Patel Richard Aspinall Gavin Wright Andrew Cook Stuart McPherson Gautam Mehta Rajiv Jalan Milton Silverman Helen Crisp |
| author_sort | Yvanne Enever |
| collection | DOAJ |
| description | Liver disease is a major, and increasing, cause of death in the UK. The UK Chronic Liver Failure network (UK-CLIF) was developed as a multi-stakeholder network with the aim to advance cirrhosis research, with emphasis on geographical areas of high disease prevalence or limited research activity. The process involved network development through dissemination and snowball sampling techniques, with monitoring of network development and connections between participants, developed over two online meetings. Network membership included representatives from patients, carers, clinicians, researchers, R&D professionals, industry representatives, and the third sector. Subsequently, two facilitated in-person workshops were conducted with network participants. World Café methodology and participant dot voting was used to develop areas of priority and consensus in: (i) research infrastructure for cirrhosis clinical trials, (ii) clinical factors affecting research delivery, and (iii) research priorities for future trials. Thematic analysis demonstrated that the need for patient-centric trial materials, a lack of resource for clinicians to participate in research, and variability in the standard of inpatient care for cirrhosis, were barriers for cirrhosis clinical trials. Future activities for UK-CLIF include participation in a process of quality standard setting for inpatient care for cirrhosis, and coordination of a James Lind Alliance Priority Setting Partnership to develop research questions for liver cirrhosis. |
| format | Article |
| id | doaj-art-1c3faf7cd73741bc972c240581f2c21a |
| institution | Kabale University |
| issn | 2633-4402 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | NIHR Open Research |
| spelling | doaj-art-1c3faf7cd73741bc972c240581f2c21a2024-12-14T01:00:00ZengF1000 Research LtdNIHR Open Research2633-44022024-11-01414841Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK [version 1; peer review: 2 approved]Yvanne Enever0Oliver Tavabie1Juan Acevedo2Richard Allen3https://orcid.org/0000-0003-0998-8249Brian Hogan4Abhishek Chauhan5Rajeshwar Mookerjee6Vishal Patel7Richard Aspinall8https://orcid.org/0000-0002-5208-8185Gavin Wright9Andrew Cook10Stuart McPherson11Gautam Mehta12https://orcid.org/0000-0002-5696-359XRajiv Jalan13Milton Silverman14Helen Crisp15Pharmexcel Limited, Welwyn Garden City, UKLeeds Teaching Hospitals NHS Trust, Leeds, UKUniversity Hospitals Plymouth NHS Trust, Plymouth, UKPPI representative, Stoke-on-Trent, UKRoyal Free London NHS Foundation Trust, London, UKUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, UKUCL Institute for Liver and Digestive Health, London, UKKing's College Hospital NHS Foundation Trust, London, UKPortsmouth Hospitals University NHS Trust, Portsmouth, UKMid and South Essex NHS Foundation Trust, Basildon, UKClinical Trials Unit, University of Southampton, Southampton, UKNewcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UKUCL Institute for Liver and Digestive Health, London, UKUCL Institute for Liver and Digestive Health, London, UKPPI representative, Stoke-on-Trent, UKUCL Institute for Liver and Digestive Health, London, UKLiver disease is a major, and increasing, cause of death in the UK. The UK Chronic Liver Failure network (UK-CLIF) was developed as a multi-stakeholder network with the aim to advance cirrhosis research, with emphasis on geographical areas of high disease prevalence or limited research activity. The process involved network development through dissemination and snowball sampling techniques, with monitoring of network development and connections between participants, developed over two online meetings. Network membership included representatives from patients, carers, clinicians, researchers, R&D professionals, industry representatives, and the third sector. Subsequently, two facilitated in-person workshops were conducted with network participants. World Café methodology and participant dot voting was used to develop areas of priority and consensus in: (i) research infrastructure for cirrhosis clinical trials, (ii) clinical factors affecting research delivery, and (iii) research priorities for future trials. Thematic analysis demonstrated that the need for patient-centric trial materials, a lack of resource for clinicians to participate in research, and variability in the standard of inpatient care for cirrhosis, were barriers for cirrhosis clinical trials. Future activities for UK-CLIF include participation in a process of quality standard setting for inpatient care for cirrhosis, and coordination of a James Lind Alliance Priority Setting Partnership to develop research questions for liver cirrhosis.https://openresearch.nihr.ac.uk/articles/4-69/v1Liver cirrhosis clinical trials alcoholeng |
| spellingShingle | Yvanne Enever Oliver Tavabie Juan Acevedo Richard Allen Brian Hogan Abhishek Chauhan Rajeshwar Mookerjee Vishal Patel Richard Aspinall Gavin Wright Andrew Cook Stuart McPherson Gautam Mehta Rajiv Jalan Milton Silverman Helen Crisp Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK [version 1; peer review: 2 approved] NIHR Open Research Liver cirrhosis clinical trials alcohol eng |
| title | Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK [version 1; peer review: 2 approved] |
| title_full | Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK [version 1; peer review: 2 approved] |
| title_fullStr | Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK [version 1; peer review: 2 approved] |
| title_full_unstemmed | Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK [version 1; peer review: 2 approved] |
| title_short | Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK [version 1; peer review: 2 approved] |
| title_sort | decompensated liver cirrhosis research network uk clif building consensus for hepatology trials in the uk version 1 peer review 2 approved |
| topic | Liver cirrhosis clinical trials alcohol eng |
| url | https://openresearch.nihr.ac.uk/articles/4-69/v1 |
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