Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020
PurposeIt is crucial to identify biomarkers that influence the aging process and associated health risks, given the growing severity of the global population aging issue. The objectives of our research were to evaluate cardiac metabolic index (CMI) as a novel biomarker for identifying individuals at...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1507035/full |
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| author | Miao Sun Shuang Bao |
| author_facet | Miao Sun Shuang Bao |
| author_sort | Miao Sun |
| collection | DOAJ |
| description | PurposeIt is crucial to identify biomarkers that influence the aging process and associated health risks, given the growing severity of the global population aging issue. The objectives of our research were to evaluate cardiac metabolic index (CMI) as a novel biomarker for identifying individuals at increased risk of accelerated biological aging and to assess its use in guiding preventive strategies for aging-related health risks.MethodsThe National Health and Nutrition Examination Survey (NHANES) provided cross-sectional data on participants with complete information on CMI, phenotypic age (PA), and other variables. Analyses of variance and weighted χ2 tests were conducted to assess differences between groups. The relationship between CMI and biological aging was investigated using a weighted multivariate logistic regression model, restricted cubic spline (RCS) regression analysis, subgroup analysis, and interaction testing.ResultsA positive correlation between CMI and biological aging was observed in 6,272 participants. RCS regression analysis confirmed the non-linear relationship, identifying significant inflection point at 1.10. In the crude or adjusted models, the OR (95% CI), for the highest group versus the reference were 3.608 (3.108, 4.188), 3.397 (2.920, 3.952), and 1.550 (1.299, 1.850), respectively, when categorizing CMI into different groups. Subgroup analyses and interaction tests indicate that the association between CMI and biological aging remained consistent across different subgroups. Gender, race, education level, marital status, poverty income ratio (PIR), drinking status and diabetes had an interaction with CMI in relation to biological aging.ConclusionAn elevated CMI is linked to increased risk for biological aging. This relationship may inform more effective prevention and treatment strategies for biological aging in the future. CMI be integrated into routine health screenings or aging assessments by healthcare professionals. |
| format | Article |
| id | doaj-art-1c2c3d827d574b65ae76fa46f2111d4a |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-1c2c3d827d574b65ae76fa46f2111d4a2024-11-29T07:10:50ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-11-011610.3389/fnagi.2024.15070351507035Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020Miao SunShuang BaoPurposeIt is crucial to identify biomarkers that influence the aging process and associated health risks, given the growing severity of the global population aging issue. The objectives of our research were to evaluate cardiac metabolic index (CMI) as a novel biomarker for identifying individuals at increased risk of accelerated biological aging and to assess its use in guiding preventive strategies for aging-related health risks.MethodsThe National Health and Nutrition Examination Survey (NHANES) provided cross-sectional data on participants with complete information on CMI, phenotypic age (PA), and other variables. Analyses of variance and weighted χ2 tests were conducted to assess differences between groups. The relationship between CMI and biological aging was investigated using a weighted multivariate logistic regression model, restricted cubic spline (RCS) regression analysis, subgroup analysis, and interaction testing.ResultsA positive correlation between CMI and biological aging was observed in 6,272 participants. RCS regression analysis confirmed the non-linear relationship, identifying significant inflection point at 1.10. In the crude or adjusted models, the OR (95% CI), for the highest group versus the reference were 3.608 (3.108, 4.188), 3.397 (2.920, 3.952), and 1.550 (1.299, 1.850), respectively, when categorizing CMI into different groups. Subgroup analyses and interaction tests indicate that the association between CMI and biological aging remained consistent across different subgroups. Gender, race, education level, marital status, poverty income ratio (PIR), drinking status and diabetes had an interaction with CMI in relation to biological aging.ConclusionAn elevated CMI is linked to increased risk for biological aging. This relationship may inform more effective prevention and treatment strategies for biological aging in the future. CMI be integrated into routine health screenings or aging assessments by healthcare professionals.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1507035/fullcardiometabolic indexbiological agingphenotypic ageNHANESchronological age |
| spellingShingle | Miao Sun Shuang Bao Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020 Frontiers in Aging Neuroscience cardiometabolic index biological aging phenotypic age NHANES chronological age |
| title | Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020 |
| title_full | Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020 |
| title_fullStr | Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020 |
| title_full_unstemmed | Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020 |
| title_short | Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020 |
| title_sort | association between cardiometabolic index and biological aging in the us population evidence from nhanes 2015 2020 |
| topic | cardiometabolic index biological aging phenotypic age NHANES chronological age |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1507035/full |
| work_keys_str_mv | AT miaosun associationbetweencardiometabolicindexandbiologicalagingintheuspopulationevidencefromnhanes20152020 AT shuangbao associationbetweencardiometabolicindexandbiologicalagingintheuspopulationevidencefromnhanes20152020 |