Macrophages infiltration and oral potentially malignant disorders: A systematic review and meta-analysis
Objective: Oral potentially malignant disorders often show a chronic inflammatory profile resulting in cellular changes at epithelial and stromal components. Since oral squamous cell carcinoma shows an association between macrophages and a worse prognosis, we hypothesize that macrophages could also...
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| Language: | English |
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Elsevier
2024-09-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024004059 |
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| author | Lara Krusser Feltraco Julia Rodrigues Fernandes Leonardo Francisco Diel Leonardo da Silva Bittencourt Lisiane Bernardi Marcelo Lazzaron Lamers |
| author_facet | Lara Krusser Feltraco Julia Rodrigues Fernandes Leonardo Francisco Diel Leonardo da Silva Bittencourt Lisiane Bernardi Marcelo Lazzaron Lamers |
| author_sort | Lara Krusser Feltraco |
| collection | DOAJ |
| description | Objective: Oral potentially malignant disorders often show a chronic inflammatory profile resulting in cellular changes at epithelial and stromal components. Since oral squamous cell carcinoma shows an association between macrophages and a worse prognosis, we hypothesize that macrophages could also be involved in the evolution of oral potentially malignant disorders into oral squamous cell carcinoma. Herein, we conducted a systematic review with meta-analysis in order to assess the role of macrophages in oral potentially malignant disorders severity and prognosis. Design: a literature search was performed encompassing all Clinical studies assessing the presence of macrophages in dysplastic and non-dysplastic tissues in relation to the prognosis of potentially malignant disorders, without restrictions on year, language, or publication status (in press). Results: Twenty-one articles fully attended the inclusion criteria, which included oral lichen planus (9/21 articles), oral leukoplakia/dysplasia (11/21 articles), oral submucous fibrosis (2/21 articles) and chronic graft-versus-host disease (1/21 articles, n = 12 patients) lesions. Most of the articles indicated that pan macrophages (CD68+) marker and the pro-tumoral M2 macrophage marker (CD163+) were distributed in the connective tissue and subepithelial compartment, with an increase in the number according to the pathological grade (mild, moderated or severe) and area of oral potentially malignant disorders (i.e epithelial or subepithelial layer). Conclusions: This systematic review indicates that there is an increase in the presence of macrophages in oral potentially malignant disorders, and these cells may be involved in the carcinogenesis process. |
| format | Article |
| id | doaj-art-1bf2ff791fb64c80976e048b48c53d6f |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-1bf2ff791fb64c80976e048b48c53d6f2025-01-09T06:16:45ZengElsevierOral Oncology Reports2772-90602024-09-0111100559Macrophages infiltration and oral potentially malignant disorders: A systematic review and meta-analysisLara Krusser Feltraco0Julia Rodrigues Fernandes1Leonardo Francisco Diel2Leonardo da Silva Bittencourt3Lisiane Bernardi4Marcelo Lazzaron Lamers5School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, BrazilSchool of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, BrazilSchool of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, BrazilDepartment of Morphological Sciences, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; State School of Professional Education in Health Hospital de Clínicas de Porto Alegre, RS, BrazilDepartment of Morphological Sciences, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, BrazilDepartment of Morphological Sciences, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Corresponding author. Department of Morphological Sciences, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, Porto Alegre, RS, CEP 90050-170, BrazilObjective: Oral potentially malignant disorders often show a chronic inflammatory profile resulting in cellular changes at epithelial and stromal components. Since oral squamous cell carcinoma shows an association between macrophages and a worse prognosis, we hypothesize that macrophages could also be involved in the evolution of oral potentially malignant disorders into oral squamous cell carcinoma. Herein, we conducted a systematic review with meta-analysis in order to assess the role of macrophages in oral potentially malignant disorders severity and prognosis. Design: a literature search was performed encompassing all Clinical studies assessing the presence of macrophages in dysplastic and non-dysplastic tissues in relation to the prognosis of potentially malignant disorders, without restrictions on year, language, or publication status (in press). Results: Twenty-one articles fully attended the inclusion criteria, which included oral lichen planus (9/21 articles), oral leukoplakia/dysplasia (11/21 articles), oral submucous fibrosis (2/21 articles) and chronic graft-versus-host disease (1/21 articles, n = 12 patients) lesions. Most of the articles indicated that pan macrophages (CD68+) marker and the pro-tumoral M2 macrophage marker (CD163+) were distributed in the connective tissue and subepithelial compartment, with an increase in the number according to the pathological grade (mild, moderated or severe) and area of oral potentially malignant disorders (i.e epithelial or subepithelial layer). Conclusions: This systematic review indicates that there is an increase in the presence of macrophages in oral potentially malignant disorders, and these cells may be involved in the carcinogenesis process.http://www.sciencedirect.com/science/article/pii/S2772906024004059CarcinogenesisTumor microenvironmentOral leukoplakiaOral lichen planusOral mucosa |
| spellingShingle | Lara Krusser Feltraco Julia Rodrigues Fernandes Leonardo Francisco Diel Leonardo da Silva Bittencourt Lisiane Bernardi Marcelo Lazzaron Lamers Macrophages infiltration and oral potentially malignant disorders: A systematic review and meta-analysis Oral Oncology Reports Carcinogenesis Tumor microenvironment Oral leukoplakia Oral lichen planus Oral mucosa |
| title | Macrophages infiltration and oral potentially malignant disorders: A systematic review and meta-analysis |
| title_full | Macrophages infiltration and oral potentially malignant disorders: A systematic review and meta-analysis |
| title_fullStr | Macrophages infiltration and oral potentially malignant disorders: A systematic review and meta-analysis |
| title_full_unstemmed | Macrophages infiltration and oral potentially malignant disorders: A systematic review and meta-analysis |
| title_short | Macrophages infiltration and oral potentially malignant disorders: A systematic review and meta-analysis |
| title_sort | macrophages infiltration and oral potentially malignant disorders a systematic review and meta analysis |
| topic | Carcinogenesis Tumor microenvironment Oral leukoplakia Oral lichen planus Oral mucosa |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024004059 |
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