Drug‐phospholipid conjugate nano‐assembly for drug delivery
Abstract Phospholipid‐based liposomes are among the most successful nanodrug delivery systems in clinical use. However, these conventional liposomes present significant challenges including low drug‐loading capacity and issues with drug leakage. Drug‐phospholipid conjugates (DPCs) and their assembli...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2024-12-01
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| Series: | Smart Medicine |
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| Online Access: | https://doi.org/10.1002/SMMD.20240053 |
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| _version_ | 1846107910145310720 |
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| author | Ding Zhao Yixiang Zhang Fan Wang Rames Kaewmanee Wenguo Cui Tianqi Wu Yawei Du |
| author_facet | Ding Zhao Yixiang Zhang Fan Wang Rames Kaewmanee Wenguo Cui Tianqi Wu Yawei Du |
| author_sort | Ding Zhao |
| collection | DOAJ |
| description | Abstract Phospholipid‐based liposomes are among the most successful nanodrug delivery systems in clinical use. However, these conventional liposomes present significant challenges including low drug‐loading capacity and issues with drug leakage. Drug‐phospholipid conjugates (DPCs) and their assemblies offer a promising strategy for addressing these limitations. In this review, we summarize recent advances in the design, synthesis, and application of DPCs for drug delivery. We begin by discussing the chemical backbone structures and various design strategies such as phosphate head embedding and mono‐/bis‐embedding in the sn‐1/sn‐2 positions. Furthermore, we highlight stimulus‐responsive designs of DPCs and their applications in treating diseases such as cancer, inflammation, and malaria. Lastly, we explore future directions for DPCs development and their potential applications in drug delivery. |
| format | Article |
| id | doaj-art-1bce2528ccc84e1e9e98ec7f5a5e0ac7 |
| institution | Kabale University |
| issn | 2751-1871 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj-art-1bce2528ccc84e1e9e98ec7f5a5e0ac72024-12-26T08:11:19ZengWiley-VCHSmart Medicine2751-18712024-12-0134n/an/a10.1002/SMMD.20240053Drug‐phospholipid conjugate nano‐assembly for drug deliveryDing Zhao0Yixiang Zhang1Fan Wang2Rames Kaewmanee3Wenguo Cui4Tianqi Wu5Yawei Du6Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Materials Science Faculty of Science Chulalongkorn University Bangkok ThailandDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Radiation Oncology Huashan Hospital Fudan University Shanghai ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaAbstract Phospholipid‐based liposomes are among the most successful nanodrug delivery systems in clinical use. However, these conventional liposomes present significant challenges including low drug‐loading capacity and issues with drug leakage. Drug‐phospholipid conjugates (DPCs) and their assemblies offer a promising strategy for addressing these limitations. In this review, we summarize recent advances in the design, synthesis, and application of DPCs for drug delivery. We begin by discussing the chemical backbone structures and various design strategies such as phosphate head embedding and mono‐/bis‐embedding in the sn‐1/sn‐2 positions. Furthermore, we highlight stimulus‐responsive designs of DPCs and their applications in treating diseases such as cancer, inflammation, and malaria. Lastly, we explore future directions for DPCs development and their potential applications in drug delivery.https://doi.org/10.1002/SMMD.20240053assemblydrug deliverydrug‐phospholipid conjugateliposomeprodrug |
| spellingShingle | Ding Zhao Yixiang Zhang Fan Wang Rames Kaewmanee Wenguo Cui Tianqi Wu Yawei Du Drug‐phospholipid conjugate nano‐assembly for drug delivery Smart Medicine assembly drug delivery drug‐phospholipid conjugate liposome prodrug |
| title | Drug‐phospholipid conjugate nano‐assembly for drug delivery |
| title_full | Drug‐phospholipid conjugate nano‐assembly for drug delivery |
| title_fullStr | Drug‐phospholipid conjugate nano‐assembly for drug delivery |
| title_full_unstemmed | Drug‐phospholipid conjugate nano‐assembly for drug delivery |
| title_short | Drug‐phospholipid conjugate nano‐assembly for drug delivery |
| title_sort | drug phospholipid conjugate nano assembly for drug delivery |
| topic | assembly drug delivery drug‐phospholipid conjugate liposome prodrug |
| url | https://doi.org/10.1002/SMMD.20240053 |
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