Intrauterine growth‐restricted pregnant rats, from placental ischemic dams, display preeclamptic‐like symptoms: A new rat model of preeclampsia

Intrauterine growth‐restricted pregnant rats, from placental ischemic dams, display preeclamptic‐like symptoms: A new rat model of preeclampsia

Abstract Preeclampsia (PE) is characterized by de novo hypertension (HTN) and is often associated with intrauterine growth restriction (IUGR). Hallmarks of PE are placental ischemia, decreased nitric oxide (NO) bioavailability, oxidative stress (OS), and organ damage in the kidneys and brain. This s...

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Bibliographic Details
Main Authors: Jonna Smith, Madison Powell, Whitney Cromartie, Savanna Smith, Kylie Jones, Angie Castillo, Jordan Shaw, Joseph Editone III, Ahfiya Howard, Robert Tatum, Alex Smith, Brandon Fisher, George W. Booz, Mark Cunningham
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Physiological Reports
Subjects:
hypertension
intrauterine growth restriction (IUGR)
nitric oxide
oxidative stress
preeclampsia
Online Access:https://doi.org/10.14814/phy2.70112
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