Long‐Term Monitoring of ApoE4 within Aqueous Humor Using Intraocular Lenses Containing Target‐Responsive Inverse Opal Hydrogel
Neurodegenerative diseases, including Alzheimer's disease (AD), pose significant challenges to global healthcare because of their irreversible postsymptomatic progression. Conventional radiographic techniques have limitations in early detection, owing to the time lapse between symptom recogniti...
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| Format: | Article |
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Wiley-VCH
2024-12-01
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| Series: | Small Structures |
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| Online Access: | https://doi.org/10.1002/sstr.202400154 |
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| author | Hyo Lee Jaewook Lim Moo‐Kwang Shin Chae‐Eun Moon Jun‐Ki Lee Jiwon Kim Yujin Kang Yong Woo Ji Seungjoo Haam |
| author_facet | Hyo Lee Jaewook Lim Moo‐Kwang Shin Chae‐Eun Moon Jun‐Ki Lee Jiwon Kim Yujin Kang Yong Woo Ji Seungjoo Haam |
| author_sort | Hyo Lee |
| collection | DOAJ |
| description | Neurodegenerative diseases, including Alzheimer's disease (AD), pose significant challenges to global healthcare because of their irreversible postsymptomatic progression. Conventional radiographic techniques have limitations in early detection, owing to the time lapse between symptom recognition by individuals and precise inspection using medical instruments. Current research explores ophthalmic approaches to address this gap, investigating the physiological link between ocular health and brain diseases. Intraocular lenses (IOLs), widely used in cataract and refractive surgeries, provide a safe and minimally invasive platform for the continuous monitoring of neurodegenerative disease biomarkers, including those associated with AD. By integrating biomolecule‐responsive sensors with IOLs, it becomes feasible to achieve early diagnosis and long‐term, noninvasive monitoring postimplantation. Herein, a fluorescently labeled inverse opal hydrogel (FIOH) is merged with IOLs for ApoE4 detection, a key risk factor for AD. The permeability and inherent photonic properties of FIOH facilitate the cumulative enhancement of the fluorescence signal. In a simulation of the aqueous humor circulation, the detection limit for ApoE4 is determined to be 0.1 nM. Therefore, FIOH‐integrated IOLs hold promise not only for early detection but also for providing a reliable platform for the continuous, noninvasive monitoring of neurodegenerative diseases after the initial, minimally invasive implantation. |
| format | Article |
| id | doaj-art-1ba8a802debc47e2bc7a3922a72d4f23 |
| institution | Kabale University |
| issn | 2688-4062 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj-art-1ba8a802debc47e2bc7a3922a72d4f232024-12-05T19:18:13ZengWiley-VCHSmall Structures2688-40622024-12-01512n/an/a10.1002/sstr.202400154Long‐Term Monitoring of ApoE4 within Aqueous Humor Using Intraocular Lenses Containing Target‐Responsive Inverse Opal HydrogelHyo Lee0Jaewook Lim1Moo‐Kwang Shin2Chae‐Eun Moon3Jun‐Ki Lee4Jiwon Kim5Yujin Kang6Yong Woo Ji7Seungjoo Haam8Department of Chemical and Biomolecular Engineering Yonsei University Seoul 03722 Republic of KoreaDepartment of Chemical and Biomolecular Engineering Yonsei University Seoul 03722 Republic of KoreaDepartment of Chemical and Biomolecular Engineering Yonsei University Seoul 03722 Republic of KoreaInstitute of Vision Research, Department of Ophthalmology Yonsei University College of Medicine Seoul 03722 Republic of KoreaInstitute of Vision Research, Department of Ophthalmology Yonsei University College of Medicine Seoul 03722 Republic of KoreaDepartment of Chemical and Biomolecular Engineering Yonsei University Seoul 03722 Republic of KoreaInstitute of Vision Research, Department of Ophthalmology Yonsei University College of Medicine Seoul 03722 Republic of KoreaInstitute of Vision Research, Department of Ophthalmology Yonsei University College of Medicine Seoul 03722 Republic of KoreaDepartment of Chemical and Biomolecular Engineering Yonsei University Seoul 03722 Republic of KoreaNeurodegenerative diseases, including Alzheimer's disease (AD), pose significant challenges to global healthcare because of their irreversible postsymptomatic progression. Conventional radiographic techniques have limitations in early detection, owing to the time lapse between symptom recognition by individuals and precise inspection using medical instruments. Current research explores ophthalmic approaches to address this gap, investigating the physiological link between ocular health and brain diseases. Intraocular lenses (IOLs), widely used in cataract and refractive surgeries, provide a safe and minimally invasive platform for the continuous monitoring of neurodegenerative disease biomarkers, including those associated with AD. By integrating biomolecule‐responsive sensors with IOLs, it becomes feasible to achieve early diagnosis and long‐term, noninvasive monitoring postimplantation. Herein, a fluorescently labeled inverse opal hydrogel (FIOH) is merged with IOLs for ApoE4 detection, a key risk factor for AD. The permeability and inherent photonic properties of FIOH facilitate the cumulative enhancement of the fluorescence signal. In a simulation of the aqueous humor circulation, the detection limit for ApoE4 is determined to be 0.1 nM. Therefore, FIOH‐integrated IOLs hold promise not only for early detection but also for providing a reliable platform for the continuous, noninvasive monitoring of neurodegenerative diseases after the initial, minimally invasive implantation.https://doi.org/10.1002/sstr.202400154Alzheimer's diseaseaqueous humorfluorescence amplificationintraocular lensinverse opal hydrogels |
| spellingShingle | Hyo Lee Jaewook Lim Moo‐Kwang Shin Chae‐Eun Moon Jun‐Ki Lee Jiwon Kim Yujin Kang Yong Woo Ji Seungjoo Haam Long‐Term Monitoring of ApoE4 within Aqueous Humor Using Intraocular Lenses Containing Target‐Responsive Inverse Opal Hydrogel Small Structures Alzheimer's disease aqueous humor fluorescence amplification intraocular lens inverse opal hydrogels |
| title | Long‐Term Monitoring of ApoE4 within Aqueous Humor Using Intraocular Lenses Containing Target‐Responsive Inverse Opal Hydrogel |
| title_full | Long‐Term Monitoring of ApoE4 within Aqueous Humor Using Intraocular Lenses Containing Target‐Responsive Inverse Opal Hydrogel |
| title_fullStr | Long‐Term Monitoring of ApoE4 within Aqueous Humor Using Intraocular Lenses Containing Target‐Responsive Inverse Opal Hydrogel |
| title_full_unstemmed | Long‐Term Monitoring of ApoE4 within Aqueous Humor Using Intraocular Lenses Containing Target‐Responsive Inverse Opal Hydrogel |
| title_short | Long‐Term Monitoring of ApoE4 within Aqueous Humor Using Intraocular Lenses Containing Target‐Responsive Inverse Opal Hydrogel |
| title_sort | long term monitoring of apoe4 within aqueous humor using intraocular lenses containing target responsive inverse opal hydrogel |
| topic | Alzheimer's disease aqueous humor fluorescence amplification intraocular lens inverse opal hydrogels |
| url | https://doi.org/10.1002/sstr.202400154 |
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