Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry

Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry

ABSTRACT Human parainfluenza virus 3 (HPIV3) infection is driven by the coordinated action of viral surface glycoproteins hemagglutinin-neuraminidase (HN) and fusion protein (F). Receptor-engaged HN activates F to insert into the target cell membrane and drive virion-cell membrane fusion. For F to m...

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Bibliographic Details
Main Authors: Kyle Stearns, George Lampe, Rachel Hanan, Tara Marcink, Stefan Niewiesk, Samuel H. Sternberg, Alexander L. Greninger, Matteo Porotto, Anne Moscona
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mBio
Subjects:
viral entry
membrane fusion
fusion protein
paramyxovirus
parainfluenza virus
proteases
Online Access:https://journals.asm.org/doi/10.1128/mbio.02327-24
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